血清尿酸与进行性核上性麻痹的相关性研究

Assessment of Serum Uric Acid Levels in Patients with Progressive Supranuclear Palsy

目的探讨血清尿酸(UA)水平与进行性核上性麻痹(PSP)的相关性。方法入组75例PSP患者(PSP组)和712例健康者(对照组),测定其空腹血清UA水平。PSP组再以发病年限3年为界值,分为PSP早期亚组和PSP晚期亚组。为分析性别对UA的影响,将PSP组分为男性亚组(48例)和女性亚组(27例),男性亚组再分为男性PSP早期亚组和男性PSP晚期亚组;女性亚组再分为女性PSP早期亚组和女性PSP晚期亚组。采用独立样本t检验比较PSP组与对照组血清UA的差异以及PSP早期亚组与PSP晚期亚组血清UA的差异,多组间比较采用单因素方差分析,线性回归分析血清UA与PSP疾病严重程度的相关性。相关因素用多因素Logistic回归分析。结果PSP组血清UA较对照组显著降低(F=15.49,P<0.001)。基于性别的血清UA水平:男性PSP亚组对比男性对照亚组(F=7.61,P=0.006);女性PSP亚组对比女性对照亚组(F=13.91,P<0.001)及PSP不同亚型[Richardson综合征型对比变异型(F=7.86,P<0.01)]的亚组分析中,差异均有统计学意义。男性晚期PSP亚组血清UA较早期PSP亚组显著降低(F=4.57,P=0.038),但女性晚期PSP亚组血清UA与早期PSP亚组比较差异无显著性(P>0.05)。血清UA和体质量指数与PSP的发生具有相关性。结论血清UA可能是PSP潜在的保护因素,本研究未发现血清UA水平作为PSP临床诊断和病程进展的生物标志物的证据。

Aim To investigate whether serum uric acid(UA)plays a role in progressive supranuclear palsy(PSP).Methods A total of 75 PSP patients and 712 healthy controls were recruited to compare serum UA levels between them.The patients with PSP were divided into early and late disease stage subgroups with 3 years of onset as the boundary value.Independent-sample t test was used to compare the differences of serum UA between PSP group and healthy control group,and the differences of serum UA between early disease stage group and late disease stage group.One-way analysis of variance was used to compare the different groups.The correlation between serum UA and PSP disease severity was analyzed by linear regression.Multiple correlation factors were analyzed by multivariate Logistic regression.Results Serum UA in PSP group was significantly lower than that in healthy control group(F=15.49,P<0.001),which was still statistically significant in subgroup analysis based on gender(PSP male vs.healthy controls male,F=7.61,P=0.006;PSP female vs.healthy controls female,F=13.91,P<0.001)and the different subtypes(PSP-Richardson group vs.PSP-atypical group,F=7.86,P<0.01)of PSP.The serum UA of the late disease stage groups was significantly lower than that of the early groups in male(F=4.57,P=0.038),but there was no statistical significance in the female group(P>0.05).Multivariate Logistic regression analysis showed that serum UA and Body Mass Index(BMI)were associated with the development of PSP.Conclusion Serum UA level may be a potential protective factor of PSP,and there was no evidence of serum UA level as a biomarker for clinical diagnosis and disease progression of PSP in this study.