摘要
普鲁兰多糖(1)是一种天然高分子聚合物,因可溶性、可塑性、可纺性、可食用性、可生物降解性、无毒性和良好的生物相容性而在医药和食品等领域广泛应用。1可作为成膜材料用于膜剂制备,作为囊材用于胶囊制备,作为生物可降解材料用于制造微针和注射剂,并可用作靶向制剂的载体材料。该文简要介绍了1的性能特点,综述了其在药物制剂中的应用现状,并展望了1未来的发展前景。
Pullulan(1),a natural polymer,has been increasingly widely used in the pharmaceutical and food industries because of its solubility,malleability,spinnability,edibility,biodegradability,non-toxicity,and well biocompatibility.It can be used as the film-forming material to prepare films,as the capsule shell material to prepare capsules,as the biodegradable material to prepare microneedles and injections,and as the carrier material for targeted drug delivery.This paper introduces the characteristics of 1,briefly reviews its current status in application in pharmaceutical preparations,and offers a prospect of 1 development.
作者
杨柳榴
李铭岩
张隽齐
王兵
陈芳
YANG Liuliu;LI Mingyan;ZHANG Junqi;WANG Bing;CHEN Fang(National Advanced Medical Engineering Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2023年第6期867-874,共8页
Chinese Journal of Pharmaceuticals
基金
国家药典委员会2021年度国家药品标准制修订研究课题项目(2021Y29)
上海科委项目(20DZ2255900)。