不同感染程度糖尿病足的病原菌及药物敏感性的回顾性分析

Retrospective analysis of pathogenic bacteria and drug sensitivity of diabetes foot with different infection degree

目的 通过检测不同感染程度的糖尿病足患者创面病原菌分布特点及药物敏感性,为临床合理用药提供指导。方法115例糖尿病足患者伤口分泌物检出65份微生物培养阳性的糖尿病足感染结果,按照糖尿病足创面的严重程度进行分类,分为中、重度感染,统计菌科、菌种、菌属,分析病原菌的分布于糖尿病足溃疡的感染程度的关系。结果 在中度感染糖尿病足创面分泌物培养病原菌中革兰氏阳性菌与革兰氏阴性菌占比接近,随着糖尿病足感染的加重,以革兰氏阴性菌为主要的病原菌比例升高(P<0.05)。结论 在糖尿病足创面感染严重的患者中,革兰氏阴性菌占比更高,应该提示患者使用有针对性的应用抗生素。

Objective The distribution characteristics and drug sensitivity of pathogenic bacteria on the wound surface of diabetes foot patients with difffferent infection degrees were detected to provide guidance for clinical rational drug use.Methods 65 cases of diabetes foot infection with positive microbial culture were detected from the wound secretion of 115 diabetic foot patients.According to the severity of diabetes foot wounds,they were classifified into moderate and severe infections.The distribution of pathogenic bacteria in the infection degree of diabetes foot ulcers was analyzed by counting the bacteria,species and genera.Results The proportion of gram-positive bacteria and gram-negative bacteria in the culture of pathogenic bacteria from the wound secretion of moderately infected diabetes foot was close.With the aggravation of diabetes foot infection,the proportion of gram-negative bacteria as the main pathogenic bacteria increased(P<0.05).Conclusions The patients with severe wound infection of diabetes foot,the proportion of gram-negative bacteria was higher,which should prompt patients to use targeted antibiotics.