美托洛尔联合胺碘酮治疗围绝经期心律失常的临床效果及对心功能和睡眠质量的影响

Clinical effect of metoprolol combined with amiodarone in the treatment of perimenopausal arrhythmia and its influence on cardiac function and sleep quality

目的探讨美托洛尔联合胺碘酮治疗围绝经期心律失常的临床效果及对心功能和睡眠质量的影响。方法回顾性分析2021年1月—2022年6月湖州市第一人民医院采用美托洛尔联合胺碘酮治疗的34例围绝经期心律失常患者为观察组,按1∶1原则选取同期采用胺碘酮治疗的34例围绝经期心律失常患者为对照组。观察比较两组治疗后临床疗效、心电图疗效、心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)]、睡眠质量(PSQI)评分以及不良反应发生情况。结果观察组临床总有效率94.12%(32/34)显著高于对照组73.53%(25/34),差异有统计学意义(P<0.05)。治疗后,观察组心电图总有效率94.12%(32/34)显著高于对照组70.59%(24/34),差异有统计学意义(P<0.05)。治疗前,两组心功能指标比较,差异无统计学意义(P>0.05)。治疗后,观察组LVESD、LVEDD值较治疗前有所降低,LVEF值较治疗前有所上升,且治疗后观察组LVESD、LVEDD低于对照组,LVEF高于对照组,差异均有统计学意义(均P<0.05)。治疗前,两组睡眠质量PSQI评分比较,差异无统计学意义(P>0.05)。治疗后,两组睡眠质量PSQI评分各维度及总分均较治疗前有所降低,且治疗后观察组睡眠质量PSQI评分各维度及总分均低于对照组(均P<0.05)。治疗后,观察组总不良反应率8.82%略低于对照组20.59%,但差异无统计学意义(P>0.05)。结论美托洛尔联合胺碘酮治疗围绝经期心律失常疗效确切,可改善心功能指标,并有利于降低睡眠质量评分。

Objective To evaluate the efficacy of metoprolol combined with amiodarone in the treatment of perimenopausal arrhythmia and its effects on cardiac function and sleep quality.Methods 34 patients with perimenopausal arrhythmia treated with metoprolol combined with amiodarone in Huzhou First People's Hospital from January 2021 to June 2022 were retrospectively analyzed as the observation group,and 34 patients with perimenopausal arrhythmia treated with amiodarone during the same period were selected as the control group according to the 1:1 principle.The clinical efficacy,electrocardiogram ficacy,cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),let ventricular ejection fraction(LVEF)],sleep quality(PSQI)score and the occurrence of adverse reactions were observed and compared between the two groups after treatment.Results The total clinical effective rate of observation group was 94.12%(32/34)significantly higher than that of control group 73.53%(25/34),the difference was statistically significant(P<0.05).Ater treatment,the total effective rate of ECG in observation group was 94.12%(32/34)significantly higher than that in control group 70.59%(24/34),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in cardiac function indexes between the two groups(P>0.05).After treatment,LVESD and LVEDD values in the observation group were lower than before treatment,and LVEF values were higher than before treatment.After treatment,LVESD and LVEDD values in the observation group were lower than those in the control group,and LVEF values were higher than those in the control group,with statistical significance(P<0.05).Before treatment,there was no significant dfference in PSQI scores of sleep quality between the two groups(P>0.05).After treatment,all dimensions and total scores of PSQI score of sleep quality in both groups were lower than before treatment,and all dimensions and total scores of PSI score of sleep quality in the observation group were lower than those in the control group after treatment(P<0.05).Conclusion Metoprolol combined with amiodarone in the treatment of perimenopausal arrhythmia is effective,can improve cardiac function index,and is beneficial to reduce sleep quality score.