磁耦合谐振式无线电能传输磁场对海马齿状回区神经元K^(+)通道的影响

The Effects of MCR-WPT Magnetic Field on Neurons K^(+)Channels in The Dentate Gyrus Region

目的磁耦合谐振式无线电能传输(magnetically-coupled resonant wireless power transfer,MCR-WPT)具有传输距离较大、传输效率高、穿透性好等优点,为人们生活带来便利的同时其引起的生物电磁效应安全问题备受人们关注。本文通过研究MCR-WPT电磁环境对小鼠海马齿状回(DG)区神经元K^(+)通道特性的影响,为无线电能传输(WPT)技术的发展及其合理开发应用提供实验依据。方法每天对小鼠不间断辐射5 h,持续30 d,对比分析对照组和磁场暴露5 d、15 d、30 d组小鼠的学习记忆能力、海马DG区神经元的瞬时外向K^(+)通道电流(IA)和延迟整流K^(+)通道电流(IK)的变化。结果磁场暴露组瞬时外向K^(+)通道的激活过程受到抑制、延迟整流K^(+)通道的激活特性向去极化方向移动,减少K^(+)的外流,增强了神经兴奋性,但磁场暴露组小鼠行为上无显著性变化。结论长期处于MCR-WPT电磁环境会改变K^(+)通道的电流-电压(I-V)特性和动力学特性,抑制IA和IK,改变神经元动作电位的发放频率,但这些变化并没有引起小鼠学习记忆能力的下降以及认知功能障碍。

Objective Magnetically-coupled resonant wireless power transfer(MCR-WPT)has the advantages of large transmission distance,high transmission efficiency and penetration,which brings convenience to people’s lives.However,the safety of bioelectromagnetic effects caused by MCR-WPT has attracted much attention.In this paper,the influence of MCR-WPT electromagnetic environment on the characteristics of neuronal K^(+)channels in the dentate gyrus(DG)region of the mouse hippocampus was studied,in order to provide an experimental basis for the development and rational development and application of WPT technology.Methods Mice were continuously irradiated for 5 h for 30 d,and the learning and memory ability,instantaneous outward K^(+)channel current(IA)and delayed rectification K^(+)channel current(IK)of neurons in the hippocampal DG region were compared and analyzed by the control group and the magnetic field exposure groups of 5 d,15 d and 30 d.Results The activation process of transient outward potassium channels in the magnetic field exposure group was inhibited,and the activation characteristics of delayed rectified potassium channels shifted to the depolarization direction,which reduced the outflow of K^(+)and enhanced the nerve excitability,but there was no significant change in the behavior of the magnetic field exposed group mice.Conclusion Long-term exposure to the electromagnetic environment of MCR-WPT altered the I-V properties and kinetic properties of K^(+)ion channels,inhibited IA and IK,and changed the frequency of neuronal action potential issuance,but these changes did not cause a decrease in learning memory capacity and cognitive dysfunction in mice.