胶质纤维酸性蛋白抗体致病机制的研究进展

Research progress on the pathogenic mechanism of glial fibrillary acidic protein antibody

自身免疫性胶质纤维酸性蛋白星形细胞病(GFAP-A)是一种新近发现的对激素敏感的复发性脑膜脑脊髓炎,其本质是自身免疫性星形胶质细胞病,血清或脑脊液中的胶质纤维酸性蛋白(GFAP)-IgG为特异性生物标志物。GFAP作为星形胶质细胞骨架中间丝蛋白,其抗体在GFAP-A的作用目前仍存在较大的争议。目前关于GFAP-IgG等细胞内抗原相关抗体的基础与临床研究不断深入,该文就GFAP-IgG可能的致病机制综述如下。

GFAP-A is a newly discovered hormone-sensitive and recurrent meningoencephalomyelitis.Its essence is autoimmune astrocytic disease,and GFAP-IgG in serum or cerebrospinal fluid is a specific biomarker.GFAP is an intermediate filament protein in the cytoskeleton of astrocytes,and the role of its antibody in GFAP-A is still controversial.At present,with the deepening of the basic and clinical research on intracellular antigen-related antibodies such as GFAP-IgG,this paper briefly introduced and discussed the possible pathogenic mechanism of GFAP-IgG.