A型肉毒毒素联合10600 nm点阵激光治疗面部皱纹的疗效观察

A Observation on the therapeutic effect of botulinum toxin type A combined with 10600 nm lattice laser in the treatment of facial wrinkles

目的 探究A型肉毒毒素联合10600 nm点阵激光治疗面部皱纹的疗效观察。方法 前瞻性选取2018年1月至2022年1月本院收治的面部皱纹患者100例为研究对象,按随机数字表法将患者分为研究组50例与对照组50例,对照组予以10600 nm点阵激光治疗,研究组在对照组基础上联合A型肉毒毒素治疗,比较两组疗效、尊严感与自信心、并发症发生情况、满意度的差异。结果 等级资料秩和检验结果显示,两组治疗后1个月疗效比较差异存在统计学意义(Z=1.010,P>0.05),但研究组治疗后3个月、治疗后6个月疗效高于对照组(Z=2.282、2.103,P<0.05)。两组治疗周后尊严感评分与治疗前比较均降低,自信心评分与治疗前比较均升高(P<0.05);且研究组治疗周后尊严感评分、自信心评分升高降低差值优于对照组(P<0.05)。两组轻微肿胀发生率、感染发生率、淤血发生率、疼痛发生率、肉芽肿、并发症总比较差异无统计学意义(P>0.05)。等级资料秩和检验结果显示,两组满意度比较差异存在统计学意义(Z=2.077,P<0.05),且研究组总满意度高于对照组(P<0.05)。结论 A型肉毒毒素联合10600 nm点阵激光治疗面部皱纹具有较好临床效果,可有效改善患者尊严感与自信心,且安全性较高,有利于提高临床满意度。

Objective To investigate the therapeutic effffect of botulinum toxin A combined with 10600 nm dot matrix laser on facial wrinkles.Method A prospective study was conducted on 100 patients with facial wrinkles admitted to our hospital from January 2018 to January 2022.The patients were randomly divided into a study group of 50 cases and a control group of 50 cases using a random number table method.The control group was treated with 10600 nm lattice laser therapy,and the study group was treated with botulinum toxin type A on the basis of the control group.The difffferences in effifficacy,sense of dignity and confifidence,incidence of complications,and satisfaction between the two groups were compared.Result The rank sum test of rank data showed a statistically signifificant difffference in effifficacy between the two groups after 1 month of treatment(Z=1.010,P>0.05),but the effifficacy of the study group was higher than that of the control group after 3 months and 6 months of treatment(Z=2.282,2.103,P<0.05).After two weeks of treatment,the sense of dignity score decreased compared to before treatment,while the confifidence score increased compared to before treatment(P<0.05);And the difffference between the increase and decrease in dignity score and confifidence score in the research group after treatment weeks was better than that in the control group(P<0.05).There was no statistically signifificant difffference in the incidence of mild swelling,infection,congestion,pain,granuloma,and complications between the two groups(P>0.05).The rank sum test results of the hierarchical data showed a statistically signifificant difffference in satisfaction between the two groups(Z=2.077,P<0.05),and the overall satisfaction of the study group was higher than that of the control group(P<0.05).Conclusion The combination of botulinum toxin A and 10600 nm lattice laser therapy for facial wrinkles has a good clinical effffect,can effffectively improve patients'sense of dignity and confifidence,and has high safety,which is benefificial for improving clinical satisfaction.