选择性自噬和动脉粥样硬化

Advances in selective autophagy and atherosclerosis

选择性自噬对降解的底物蛋白具有专一性,包括线粒体自噬、脂噬、炎症小体自噬、内质网自噬、过氧化物酶体自噬、聚集体自噬、核糖体自噬等。动脉粥样硬化(As)是一种慢性炎症性病变,其主要特征包括脂质堆积、泡沫细胞形成、内皮细胞功能障碍、血管平滑肌细胞异常增殖和局部炎症。近年来,大量研究提示选择性自噬参与As的发生发展。文章综述了选择性自噬的调控机制,以及线粒体自噬、脂噬、炎症小体自噬、内质网自噬和过氧化物酶体自噬在As中的作用及其分子机制,以期为As的防治提供新思路。

Selective autophagy is specific to degraded substrate proteins,including mitophagy,lipophagy,inflammasomophagy,reticulophagy,pexophagy,aggrephagy and ribophagy,etc.Atherosclerosis(As)is a chronic inflammatory disease mainly characterized by lipid accumulation,foam cell formation,endothelial cell dysfunction,abnormal proliferation of vascular smooth muscle cell,and local inflammation.In recent years,a large number of studies have suggested that selective autophagy is involved in the development of As.This paper reviewed the regulatory mechanisms of selective autophagy,and the potential roles of mitophagy,lipophagy,inflammasomophagy,reticulophagy and pexophagy in As,which can provide new ideas for the treatment of As.