同型半胱氨酸、血脂水平在高血压患者中的应用价值研究

Application Value of Homocysteine and Blood Lipid Levels in Patients with Hypertension

目的探究同型半胱氨酸、血脂水平在高血压患者中的应用价值。方法选取徐州市肿瘤医院2021年1月—2023年5月期间收治的60例高血压患者为观察组,按照血压水平不同,将其分为观察1组141~160/91~100 mmHg(n=4)、观察2组>160~<181/>100~110 mmHg(n=32)、观察3组≥181/>110 mmHg(n=24)另选取同期于本院接受诊疗的60例其他疾病非高血压患者为对照组。比较血压指标、同型半胱氨酸与血脂水平,以及不同血压指标下同型半胱氨酸与血脂水平。结果观察组收缩压、舒张压与高同型半胱氨酸(homocysteine,Hcy)水平、三酰甘油、总胆固醇、低密度脂蛋白为(98.27±4.65)mmHg、(169.56±11.71)mmHg、(50.03±13.56)μmol/L、(2.62±0.86)mmol/L、(5.04±1.01)mmol/L、(3.22±0.37)mmol/L,均较对照组的(79.04±2.72)mmHg、(116.38±4.75)mmHg、(10.62±2.51)μmol/L、(1.51±0.32)mmol/L、(4.08±1.07)mmol/L、(2.38±0.61)mmol/L更高,高密度脂蛋白为(0.92±0.17)mmol/L,较对照组的(1.57±0.48)mmol/L更低,,差异有统计学意义(t=27.650、32.598、22.136、9.370、5.054、9.120、9.888,P<0.05)。观察3组患者的Hcy与血脂水平最高,且患者血压指标越高,Hcy水平越高,高密度脂蛋白有所降低,差异有统计学意义(P<0.05)。结论不同血压状态下患者机体同型半胱氨酸、血脂水平均存在差异,能够依据指标的变化实现患者病情评估,对于患者疾病治疗指导有显著价值。

Objective To explore the application value of homocysteine and blood lipid levels in patients with hyper⁃tension.Methods 60 hypertensive patients admitted to Xuzhou Cancer Hospital from January 2021 to May 2023 were selected as the observation group.According to different blood pressure levels,they were divided into observation group 1,141-160/91-100 mmHg(n=4),observation group 2,>160-<181/>100-110 mmHg(n=32),observation group 3≥181/>110 mmHg(n=24).Additionally,60 non hypertensive patients with other diseases who received diagnosis and treatment in our hospital during the same period were selected as the control group.Compare blood pressure indica⁃tors,homocysteine and blood lipid levels,as well as homocysteine and blood lipid levels under different blood pres⁃sure indicators.Results The systolic and diastolic blood pressure,homocysteine(hcy)levels,triglycerides,total choles⁃terol,and low-density lipoprotein in the observation group were(98.27±4.65)mmHg,(169.56±11.71)mmHg,and(50.03±13.56)mmHg,respectivelyμmol/L,(2.62±0.86)mmol/L,(5.04±1.01)mmol/L,and(3.22±0.37)mmol/L were all higher than those in the control group(79.04±2.72)mmHg,(116.38±4.75)mmHg,and(10.62±2.51)μmol/L,(1.51±0.32)mmol/L,(4.08±1.07)mmol/L,and(2.38±0.61)mmol/L were higher,while high-density lipoprotein was(0.92±0.17)mmol/L,which was lower than the control group's(1.57±0.48)mmol/L,and the difference was statistically significant(t=27.650,32.598,22.136,9.370,5.054,9.120,9.888,P<0.05).The Hcy and blood lipid levels were ob⁃served to be the highest in the three groups of patients,and the higher the blood pressure indicators,the higher the Hcy level,and the lower the high-density lipoprotein,the difference was statistically significant(P<0.05).Conclusion There are differences in homocysteine and blood lipid levels in patients with different blood pressure states,which can realize the disease assessment of patients according to the changes of indicators,and has significant value for the treat⁃ment of patients.