研究超敏C-反应蛋白联合血常规对小儿支气管炎的诊断效果

Diagnostic Effect of Hypersensitive C-reactive Protein Combined with Blood Routine in Children with Bronchitis

目的 探讨小儿支气管炎采用超敏C-反应蛋白(high-sensitivity C-reactive protein, hs-CRP)联合血常规诊断的效果。方法 选取2022年1—12月菏泽市妇幼保健院收治的68例支气管炎患儿作为观察组,另选取同期40例健康体检儿童作为对照组,均接受hs-CRP、血常规检验,统计两组hs-CRP、白细胞计数(white blood cell, WBC)水平,比较单一检测与联合检测的阳性检出率及诊断效能。结果 观察组hs-CRP(14.93±2.67)mg/L、WBC(13.72±3.19)×10^(9)/L水平较对照组[(7.29±1.14)mg/L、(6.07±1.38)×10^(9)/L]更高,差异有统计学意义(P<0.05);hs-CRP检测诊断灵敏度为70.59%,特异度为75.00%,阳性预测值为82.76%,阴性预测值为60.00%,准确性为72.22%,血常规检测分别为63.24%、67.50%、76.79%、51.92%、64.81%,联合检测分别为91.18%、97.50%、98.41%、86.67%、93.52%,联合检测诊断效能(灵敏度、特异度、阳性预测值、阴性预测值、准确性)高于单一检测,差异有统计学意义(P<0.05)。结论 hs-CRP联合血常规应用于小儿支气管炎诊断中,能够提高阳性检出率,提升诊断效能,应用价值较高。

Objective To explore the diagnostic effect of hypersensitive C-reactive protein(hs-CRP)combined with blood routine in children with bronchitis.Methods A total of 68 children with bronchitis treated in Heze Maternal and Child Health Hospital from January to December 2022 were selected as the observation group,and 40 healthy chil⁃dren in the same period were selected as the control group.All of them received hs-CRP and blood routine tests.The levels of hs-CRP and white blood cell count(WBC)in the two groups were measured,and the positive detection rate and diagnostic efficiency of single detection and combined detection were compared.Results The levels of hs-CRP(14.93±2.67)mg/L and WBC(13.72±3.19)×10^(9)/L in observation group were higher than those in control group[(7.29±1.14)mg/L,(6.07±1.38)×10^(9)/L],and the difference was statistically significant(P<0.05).The hs-CRP test had a diag⁃nostic sensitivity of 70.59%,a specificity of 75.00%,a positive predictive value of 82.76%,a negative predictive value of 60.00%,and an accuracy of 72.22%,and blood routine test was 63.24%,67.50%,76.79%,51.92%,64.81%,and combined test was 91.18%,97.50%,98.41%,86.67%,93.52%,respectively.The diagnostic efficacy(sensitivity,specificity,positive predictive value,negative predictive value,accuracy)of combined test was higher than that of single test,and the difference was statistically significant(P<0.05).Conclusion The application of hs-CRP combined blood routine in the diagnosis of bronchitis in children can improve the positive detection rate,promote the improve⁃ment of diagnostic efficiency,and have high application value.