贝伐单抗对于结直肠癌靶向治疗的临床效果

Clinical Efficacy of Bevacizumab in Targeted Therapy for Colorectal Cancer

目的 探析贝伐单抗对于结直肠癌靶向治疗的临床效果。方法 选取2021年1月—2023年3月宜兴市肿瘤医院收治的50例结直肠癌患者作为研究对象,以计算机软件为基础分为两组,每组25例,对照组实施奥沙利铂联合卡培他滨,观察组开展贝伐单抗联合奥沙利铂,对比两组相关指标。结果 观察组有效率为100.00%,高于对照组的60.00%,差异有统计学意义(χ^(2)=8.140,P<0.05)。干预前,两组肿瘤标志物水平、免疫功能比较,差异无统计学意义(P>0.05);干预后,观察组肿瘤标志物水平低于对照组,免疫功能优于对照组,差异有统计学意义(P<0.05)。干预前,两组生存质量评分比较,差异无统计学意义(P>0.05);干预后,观察组生存质量评分高于与对照组,差异有统计学意义(P<0.05)。结论 对结直肠癌患者实施贝伐单抗+奥沙利铂治疗,其肿瘤标志物与免疫功能相关指标得到显著调整,并改善治疗效果与生存质量。

Objective To explore the clinical effect of bevacizumab in targeted therapy of colorectal cancer.Methods A total of 50 colorectal cancer patients admitted to Yixing Tumor Hospital from January 2021 to March 2023 were se⁃lected as the research objects.They were divided into two groups based on computer software,with 25 cases in each group.The control group was treated with oxaliplatin combined with capecitabine,and the observation group was treated with bevacizumab combined with oxaliplatin.The related indicators of the two groups were compared.Results The effective rate of the observation group was 100.00%,which was higher than 60.00%of the control group,and the difference was statistically significant(χ2=8.140,P<0.05).Before intervention,there was no statistically significant dif⁃ference in the levels of tumor markers and immune function between the two groups(P>0.05).After intervention,the level of tumor markers in the observation group was lower than that in the control group,and the immune function was better than that in the control group,the differences were statistically significant(P<0.05).Before intervention,there was no statistically significant difference in quality of life scores between the two groups(P>0.05);after intervention,the quality of life score of the observation group was higher than that of the control group,and the difference was statis⁃tically significant(P<0.05).Conclusion The implementation of bevacizumab+oxaliplatin therapy in patients with colorectal cancer has significantly adjusted tumor markers and immune function related indicators,and improved the treatment effect and quality of life of patients.