中性粒细胞/淋巴细胞比率在视神经脊髓炎谱系疾病中的临床价值分析

Analysis of the Clinical Value of Neutrophil/lymphocyte Ratio in Neuromyelitis Optica Spectrum Diseases

目的分析中性粒细胞与淋巴细胞的比率(neutrophil to lymphocyte ratio,NLR)在视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)中的临床价值。方法选取2019年7月—2022年8月于新疆医科大学第一附属医院就诊的初诊NMOSD患者52例作为NMOSD组,同时选择同时期的健康体检者30例作为对照组;比较NMOSD组和对照组的基本资料,分析NLR识别重度神经功能缺损的临床价值。结果NMOSD组患者中性粒细胞和NLR均高于对照组,淋巴细胞低于对照组,差异有统计学意义(P<0.05)。NLR识别重度神经功能缺损的ROC曲线下面积是0.879(95%CI:0.864~7.089,P<0.001)。结论NLR可作为识别重度神经功能缺损的重要指标,对于评价NMOSD患者的病情变化情况具有重要意义。

Objective To analyze the clinical value of neutrophil to lymphocyte ratio(NLR)in neuromyelitis optica spectrum disoder(NMOSD).Methods 52 newly diagnosed NMOSD patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from July 2019 to August 2022 were selected as the NMOSD group,and 30 healthy persons who underwent physical examination during the same period were selected as the control group.Compare the basic information of the NMOSD group and the control group.Analyze the clinical value of NLR in identifying severe neurological deficits.Results Neutrophils and NLR in NMOSD group were higher than those in control group,and lymphocytes was lower than that in control group,the difference was statistically significant(P<0.05).The area under ROC curve for NLR to identify severe neurological impairment was 0.879(95%:CI 0.864-7.089,P<0.001).Conclusion NLR can be used as an important indicator to identify severe neurological deficits,and is of great significance for evaluating the condition changes of NMOSD patients.