血小板、心肌肌钙蛋白联合检测对冠心病患者的诊断价值

Diagnostic Value of Combined Determination of Platelet and Cardiac Tro ponin in Patients with Coronary Heart Disease

目的探讨血小板联合心肌肌钙蛋白检测用于临床诊断冠状动脉粥样硬化性心脏病(简称冠心病)的价值。方法选择2021年9月—2022年12月丰县人民医院收治的冠心病住院患者105例作为观察组,选择同期于本院进行体检的健康者105例作为对照组,分别进行血小板指标、心肌肌钙蛋白指标检测,记录检测结果,进行组间对比。另外计算血小板检测、心肌肌钙蛋白检测及二者联合检测诊断冠心病的准确率、灵敏度及特异性。结果观察组红细胞分布宽度(red blood cell volume distribution width,RDW)、血小板计数(blood platelet,PLT)、平均血小板体积(mpvmeanplateletvolume,MPV)、红细胞计数(red blood cell,RBC)及平均红细胞体积(erythrocyte mean corpuscular volume,MCV)水平均明显高于对照组,差异有统计学意义(P<0.05)。观察组肌红蛋白(myoglobin,Mb)、脑利尿钠肽(brain natriuretic peptide,BNP)、超敏肌钙蛋白I(high-sensitivitycardiactroponinI,Hs-cTnI)及肌酸激酶同工酶(creatine kinase-MB,CK-MB)水平均高于对照组,差异有统计学意义(P<0.05)。血小板联合心肌肌钙蛋白检测冠心病的灵敏度、准确率分别为100%、98.57%,均明显高于单一方法检测,差异有统计学意义(P<0.05)。结论临床诊断冠心病可通过血小板指标、心肌肌钙蛋白指标二者联合检测的方式,相比单一检测方式具有更高的灵敏度与准确率,且能够为后续疾病的治疗提供准确检验数值。

Objective To investigate the value of platelet combined with myocardial troponin detection in clinical diagnosis of coronary atherosclerotic heart disease(coronary heart disease,CHD).Methods 105 hospitalized patients with coronary heart disease admitted to Fengxian People's Hospital from September 2021 to December 2022 were selected as the observation group,and 105 healthy individuals who underwent physical examinations in our hospital during the same period were selected as the control group.Platelet and cardiac troponin indicators were tested,and the test results were recorded for inter group comparison.Additionally,calculate the accuracy,sensitivity,and specificity of platelet testing,cardiac troponin testing,and a combination of the two for diagnosing coronary heart disease.Results The levels of red blood cell volume distribution width(RDW),blood platelet count(PLT),meanplateletvolume(MPV),red blood cell count(RBC)and erythrocyte mean corpuscular volume(MCV)in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The levels of Myoglobin(myoglobin,Mb),brain diuresis sodium peptide(brain natriuretic peptide,BNP),allergic troponin I(high-sensitivitycardiactroponinI,Hs-cTnI)and creatine kinase-MB(CK-MB)in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The sensitivity and accuracy of platelet combined with cardiac troponin in detecting coronary heart disease were 100%and 98.57%,respectively,which were significantly higher than those of single method detection,and the difference was statistically significant(P<0.05).Conclusion Clinical diagnosis of coronary heart disease can be through the combined detection of platelet indexes and myocardial troponin indexes,which has higher sensitivity and accuracy compared with a single detection method,and can provide accurate test values for the subsequent treatment of diseases.