舒更葡糖钠用于胸腹腔镜食管癌根治术患者对术后早期恢复的影响分析

Analysis of the Effect of Sugammadex Sodium Used in Patients Undergoing Thoracolaparoscopic Radical Esophageal Cancer Surgery on Early Postoperative Recovery

目的探讨针对胸腹腔镜食管癌根治术患者使用舒更葡糖钠对术后早期恢复的影响。方法方便选取2021年1月—2023年2月厦门医学院附属第二医院收治的96例胸腹腔镜食管癌根治术患者为研究对象,采用随机数表法分为对比组和观察组,每组48例。在手术过程中,两组患者使用相同的麻醉诱发方式,其中对比组配合使用新斯的明与阿托品联合方法对患者进行给药;观察组配合使用舒更葡糖钠对患者进行给药,对比两组治疗效果。结果两组各术中指标及首次排便时间比较,差异无统计学意义(P>0.05)。观察组首次排气时间(23.28±3.66)h短于对比组(30.44±3.94)h,差异有统计学意义(t=9.224,P<0.05)。观察组拔管时间、TOFr恢复至0.9的时间均短于对比组,差异有统计学意义(P<0.05)。观察组应用肌肉拮抗药后5、15 min的肌松残余率均低于对比组,差异有统计学意义(P<0.05)。应用肌肉拮抗药后30 min,两组的肌松残余率比较,差异无统计学意义(P>0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论通过应用舒更葡糖钠,能够使胸腹腔镜食管癌根治术患者术后早期恢复效果得到提升。

Objective To explore the effect analyze the specific methods of using Sugammadex sodium in patients undergoing thoracolaparoscopic radical esophageal cancer surgery on early postoperative recovery.Methods A total of 96 patients with radical resection of thoracic esophageal cancer treated in the Second Affiliated Hospital of Xiamen Medical College from January 2021 to February 2023 were conveniently selected as the study objects,and were divided into comparison group and observation group by random number table method,with 48 cases in each group.During the operation,the same anesthesia induction method was used in the two groups.The comparison group was administered with neostigmine combined with atropine.Patients in the observation group were administered with Sugannose sodium,and the therapeutic effect of the two groups was compared.Results There was no statistically significant difference in intraoperative indexes and first defecation time between the two groups(P>0.05).The first exhaust time of observation group(23.28±3.66)h was shorter than that of comparison group(30.44±3.94)h,and the difference was statistically significant(t=9.224,P<0.05).The extubation time and the recovery time of TOFr to 0.9 in the observation group were shorter than those in the comparison group,and the difference was statistically significant(P<0.05).The residual rate of muscle relaxation in the observation group was lower than that in the comparison group 5 and 15 min af ter the application of muscle antagonist,and the difference was statistically significant(P<0.05).30 minutes after the application of muscle antagonist,there was no statistically significant difference in the residual rate of muscle relaxation between the two groups(P>0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The early recovery effect of patients undergoing laparoscopic radical resection of esophageal cancer can be improved by the application of sulgen sodium.