C反应蛋白与白蛋白比值对重症缺血性卒中预后的判断价值

Diagnosis Value of C-Reactive Protein to Albumin Ratio for Severe Ischemic Stroke

目的 探讨C反应蛋白(CRP)与白蛋白(ALB)比值对判定重症缺血性卒中预后的价值。方法 选取2022年2月-2023年3月本院收治的71例重症缺血性卒中者为观察组,将同期接收的70例健康体检者为对照组。收集患者一般资料及生化检验指标,进行对症治疗并且在治疗1个月后应用改良Rankin量表(m RS)评价预后,根据预后情况将其分成预后良好组(50例)与预后不良组(21例)。比较两组一般资料及生化检验结果,对不同预后组的结果对比,采取多因素Logistic回归分析评价重症缺血性卒中预后的相关影响因素。结果 观察组CRP、CRP/ALB水平高于对照组,ALB水平低于对照组,对比差异具有统计意义(P<0.05);预后良好组的美国国立卫生研究院卒中量表(NIHSS)评分、CRP、CRP/ALB水平均低于预后不良组,预后良好组的ALB水平高于预后不良组,差异具有统计意义(P<0.05)。研究组与对照组、预后良好组与预后不良组在性别、年龄、吸烟、高血压病史、收缩压、舒张压方面的比较差异均无统计意义(P>0.05)。多因素Logistic回归分析表明,NIHSS评分、CRP、CRP/ALB均属于重症缺血性卒中患者危险因素,ALB属于保护因素。结论 CRP/ALB比值在重症缺血性卒中患者中会升高,同时预后不良患者的CRP/ALB比值也更高,因此可作为重症缺血性卒中预后评估重要标志物。

Objective To explore value of C-reactive protein(CRP)to albumin(ALB)ratio in determining prognosis of severe ischemic stroke.Methods The paper chose 71 patients with severe ischemic stroke from February 2022 to March 2023 as observation group,and 70 healthy individuals admitted during the same period as control group,and collected general data and biochemical test indicators of patients,with symptomatic treatment,and evaluated prognosis with modified Rankin Scale(mRS)one month after treatment,and divided them into good prognosis group(50 cases)and bad prognosis group(21 cases)according to prognosis.General data and biochemical test results between different prognostic groups were compared.Related influencing factors for prognosis of severe ischemic stroke was evaluated with multivariate logistic regression analysis.Results CRP and CRP/ALB levels in observation group were higher than control group,while ALB level was lower than control group,comparison showed statistically significant difference(P<0.05).National Institutes of Health Stroke Scale(NIHSS)scores,CRP,CRP/ALB levels in the group with good prognosis were lower than the group with poor prognosis.ALB level in the group with good prognosis was higher than that the group with poor prognosis,difference was statistically significant(P<0.05).There was no statistically significant difference in gender,age,smoking,history of hypertension,systolic and diastolic blood pressure between observation group and the control group,and between group with good prognosis and group with poor prognosis(P>0.05).Multivariate logistic regression analysis showed,NIHSS scores,CRP,CRP/ALB were risk factors of severe ischemic stroke patients,while ALB was protective factor.Conclusion CRP/ALB ratio increases of patients with severe ischemic stroke,and the CRP/ALB ratio for patients with poor prognosis is higher, which is an important marker for evaluating prognosis of severe ischemic stroke.