加贝酯联合乌司他丁对急性胰腺炎患者临床症状改善及炎症指标的影响

Effect of Gabetate combined with Ulinastatin on Improvement of Clinical Symptoms and Inflammatory Indexes in Patients with Acute Pancreatitis

目的探讨加贝酯联合乌司他丁对急性胰腺炎患者临床症状改善及炎症指标的影响。方法选取2020年1月至2022年1月葫芦岛市中心医院收治的60例急性胰腺炎患者作为研究对象,用抽签法随机分为观察组与对照组,各30例。对照组采用加贝酯治疗,观察组在对照组基础上联用乌司他丁,比较两组的治疗效果。结果观察组腹胀消失时间、淀粉酶恢复正常时间、腹痛消失时间、排气时间和肠鸣音恢复时间明显短于对照组(P<0.05);治疗前,两组血清脂质过氧化物(LPO)、过氧化氢酶(CAT)和超氧化物歧化酶(SOD)水平比较差异无统计学意义(P>0.05);治疗后,两组血清LPO水平明显降低(P<0.05),CAT和SOD水平明显升高(P<0.05),且观察组血清LPO水平明显低于对照组(P<0.05),CAT和SOD水平明显高于对照组(P<0.05);治疗前,两组血清降钙素原(PCT)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)水平比较差异无统计学意义(P>0.05);治疗后,两组血清PCT、IL-6、hs-CRP、IL-1β和TNF-α水平明显降低(P<0.05),且观察组血清PCT、IL-6、hs-CRP、IL-1β和TNF-α水平明显低于对照组(P<0.05);治疗前,两组尿淀粉酶、血清脂肪酶及淀粉酶水平比较差异无统计学意义(P>0.05);治疗后,两组尿淀粉酶、血清脂肪酶及淀粉酶水平明显降低(P<0.05),且观察组尿淀粉酶、血清脂肪酶及淀粉酶水平明显低于对照组(P<0.05)。结论加贝酯联合乌司他丁治疗急性胰腺炎疗效显著,能快速改善患者的临床症状,减轻氧化应激,缓解机体的炎症反应。

ObjectiveTo explore the effect of gabetate combined with ulinastatin on the improvement of clinical symptoms and inflammatory indexes in patients with acute pancreatitis.Methods Sixty patients with acute pancreatitis admitted to Huludao Central Hospital from January 2020 to January 2022 were selected as the study objects and randomly divided into observation group and control group by drawing lots,with 30 cases in each group.The control group was treated with gabetate,the observation group was treated with ulinastatin on the basis of the control group,and the therapeutic effect of the two groups was compared.Results The disappearance time of abdominal distension,amylase normalizing time,abdominal pain disappearance time,exhaust time and intestinal sound recovery time in observation group were significantly shorter than those in control group(P<0.05).Before treatment,there was no significant difference in serum lipid peroxidase(LPO),catalase(CAT)and superoxide dismutase(SOD)levels between 2 groups(P>0.05).After treatment,the serum LPO level of the two groups was significantly decreased(P<0.05),the CAT and SOD levels were significantly increased(P<0.05),and the serum LPO level of the observation group was significantly lower than that of the control group(P<0.05),and the CAT and SOD levels were significantly higher than that of the control group(P<0.05).Before treatment,there were no significant differences in serum levels of procalcitonin(PCT),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)between 2 groups(P>0.05).After treatment,the levels of serum PCT,IL-6,hs-CRP,IL-1βand TNF-αin 2 groups were significantly decreased(P<0.05),and the levels of serum PCT,IL-6,hs-CRP,IL-1βand TNF-αin observation group were significantly lower than those in control group(P<0.05).Before treatment,there was no significant difference in urinary amylase,serum lipase and amylase levels between the two groups(P>0.05).After treatment,the levels of urine amylase,serum lipase and amylase in both groups were significantly decreased(P<0.05),and the levels of urine amylase,serum lipase and amylase in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Gabetate combined with ulinastatin is effective in the treatment of acute pancreatitis,which can quickly improve the clinical symptoms of patients,reduce oxidative stress and relieve the inflammatoryresponseof thebody.