某院近3年抗高血压药物使用情况

Use of Antihypertensive Drugs in A Hospital in Recent 3 Years

目的探讨某院近3年抗高血压药物使用情况。方法抽取2018年1月至2020年12月三亚中心医院(海南省第三人民医院)门诊、住院患者所开具的40987张含抗高血压药的处方进行调查研究。对处方中的患者年龄、性别等基本信息进行统计,并分析处方中药物种类、用药频度(DDDs)、单品抗高血压药物使用情况、药物利用指数(DUI)、联合用药情况。结果2018年、2019年、2020年女性患者比例均高于男性,在年龄统计中均以61~75岁年龄段患者比例最高;2018年、2019年、2020年患者使用抗高血压药物种类中,以CCB应用比例最高,达41.92%、39.94%、39.23%;2018年、2019年、2020年抗高血压药物中DDDs最高药物分别为硝苯地平控释片、厄贝沙坦片;2018年、2019年、2020年单品抗高血压药使用频率最高的是硝苯地平控释片,连续3年排列第一,使用率分别为21.50%、21.83%、22.20%,其次为硝苯地平、左旋氨氯地平;2018年、2019年、2020年DUI统计排名第一的分别为氢氯噻嗪片、酒石酸美托洛尔片、缬沙坦胶囊;通过对2018年、2019年、2020年联合用药情况进行分析,单一用药方式连续3年排名第一,分别为52.64%、54.14%、50.62%,其次为二联用药、三联用药。结论本院2018—2020年临床使用的抗高血压药物种类齐全,多数药物为指南推荐,包括CCB、ARB等。在联合用药方面,主要为单独用药和二联用药,联合滥用现象较少,合理性较高。

Objective To explore the use of antihypertensive drugs in a hospital in recent 3 years.Methods A total of 40987 prescriptions containing antihypertensive drugs issued by outpatients and inpatients of Sanya Central Hospital(the Third People's Hospital of Hainan Province)from January 2018 to December 2020 were selected for investigation and study.The patients'age,gender and other basic information in the prescription were analyzed,and the types of drugs,DDDs,single antihypertensive drug use,drug utilization index(DUI),and combined drug use in the prescription were analyzed.Results In 2018,2019 and 2020,the proportion of female patients was higher than that of male patients,and the proportion of 61~75 years old patients was the highest in age statistics.Among the types of antihypertensive drugs used by patients in 2018,2019 and 2020,the proportion of CCB was the highest,reaching 41.92%,39.94%and 39.23%.The highest DDDs of antihypertensive drugs in 2018,2019 and 2020 were nifedipine controlled release tablets,nifedipine controlled release tablets and irbesartan tablets,respectively.From the analysis of the use frequency of single antihypertensive drugs in 2018,2019 and 2020,the use frequency of nifedipine controlled-release tablets was the highest,ranking the first for three consecutive years,and the use rate was 21.50%,21.83%and 22.20%,respectively,followed by nifedipine and levamlodipine.The top DUI rankings in 2018,2019 and 2020 were hydrochlorothiazide tablets,Metoprolol tartrate tablets and valsartan capsules,respectively.Through the analysis of combined drug use in 2018,2019 and 2020,single drug use ranked first for three consecutive years,which were 52.64%,54.14%and 50.62%respectively,followed by double drug use and triple drug use.ConclusionThe clinical use of antihypertensive drugs in our hospital from 2018 to 2020 is complete,most of which are recommended by guidelines,including CCB,ARB,etc.In the aspect of combined drug use,it is mainly single drug use and double drug use,and the combined abuse phenomenon is less and the rationality is higher.