直肠癌MUSE-DWI与常规DWI成像对比研究

A comparative study on using MUSE-DWI and conventional DWI imaging of rectal cancer

目的:对比分析基于复合灵敏度编码的高分辨率磁共振扩散成像(MUSE-DWI)与常规扩散加权成像(DWI)在直肠癌的成像质量。方法:回顾性纳入分析桂林医学院附属医院2021年11月-2022年6月经病理确诊为直肠癌的48例患者资料,采用3.0T磁共振进行常规序列扫描,以及进行MUSE-DWI和单次激发自旋回波平面成像(SS-EPI)图像对比研究。由2名放射科医师分别对2组DWI图像进行主观和客观评价。主观评价:采用5分法对病变可见性、病灶变形、轮廓清晰度、伪影水平以及图像噪声进行评分。客观评价:对信噪比(SNR)、对比度(CR)、表观扩散系数(ADC)以及病灶最大横纵径测量计算。主观评分一致性采取Kappa检验,以及采取配对t检验、Wilcoxon秩和检验比较图像质量客观评分之间的差异。结果:MUSE-DWI在病变可见性、几何变形、轮廓清晰度、磁敏感伪影以及图像整体质量的评分均高于SS-EPI DWI,差异具有统计学意义(P<0.001)。客观评价得出MUSE-DWI的SNR、CNR均优于常规DWI(P<0.001),2组DWI间的ADC值差异无统计学意义(P=0.55),并且直肠病变的最大纵径差异有统计学意义(P<0.05),最大横径差异无统计学意义(P=0.61)。结论:MUSE-DWI明显的改善了直肠癌图像质量,较SS-EPI DWI成像提高了图像分辨率,减少了病灶的几何变形,从而实现了直肠DWI的高分辨率成像。

Objective:To compare the imaging quality of high-resolution magnetic resonance diffusion imaging based on multiplexed sensitivity encoding(MUSE-DWI)and conventional diffusion weighted imaging(DWI)in rectal cancer.Methods:The data of 48 patients diagnosed as rectal cancer by pathological biopsy in Affiliated Hospital of Guilin Medical University from November 2021 to June 2022 were retrospectively analyzed.The routine sequence scanning was performed by 3.0 Tesla magnetic resonance,and MUSE-DWI and single-shot spin echo planar imaging(SS-EPI DWI)were compared.The two groups of DWI images were subjectively and objectively evaluated by two radiologists.Subjective evaluation:lesion visibility,lesion deformation,contour sharpness,artifact level and image noise were sored using a 5-point scale.Objective evaluation:signal-to-noise ratio(SNR),contrast ratio(CR),apparent diffusion coefficient(ADC)maximum transverse and longitudinal diameters of lesions were calculated.Kappa test was applied to verify the consistency of subjective scores,and paired t-test and Wilcoxon rank sum test were used to compare the differences between objective scores for image quality.Results:MUSE-DWI had higher scores than that of SS-EPI DWI in lesion visibility,geometric deformation,contour sharpness,sensitivity artifact and overall image quality(P<0.001).Objective evaluation showed that the SNR and CNR of MUSE-DWI were superior to conventional DWI(P<0.001),and the difference in ADC value between the two groups was not statistically significant(P=0.55).Moreover,the maximum longitudinal diameter of rectal lesions was statistically significant(P<0.05),while the maximum transverse diameter was not statistically significant(P=0.61).Conclusion:MUSE-DWI may significantly improve the image quality of rectal cancer,enhances the image resolution and reduces the geometric deformation of lesions compared with SS-EPI DWI imaging,so as to realize the high-resolution imaging of rectal DWI.