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血清生化炎症因子对老年骨科创伤患者术后感染及血栓发生的临床预测价值 被引量:1

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摘要 目的 探讨血清生化炎症因子水平对老年骨科创伤患者术后感染及血栓发生的临床预测价值。方法 选取157例老年骨科创伤患者,根据术后发生感染分为感染组(39例)及非感染组(118例)。同时根据患者术后发生急性下肢深静脉血栓(DVT)分为DVT组(27例)及非DVT组(130例)。对比不同组间术前血清白细胞介素(IL)-6、IL-17、IL-23及肿瘤坏死因子(TNF)-α水平。相关性分析确定各血清炎症因子间的关联。单因素及多因素Logistic回归分析评价血清生化炎症因子指标对骨科创伤术后感染及血栓发生的临床预测价值。结果 感染组血清IL-6、IL-17、IL-23及TNF-α水平显著高于非感染组(P<0.05)。DVT组IL-6、IL-17、IL-23及TNF-α水平高于非DVT组,差异有统计学意义(P<0.05)。相关性分析显示IL-17与IL-23存在显著相关性(P<0.05),IL-6与IL-17、IL-23及TNF-α存在显著相关性(P<0.05)。多因素Logistic回归分析显示IL-6及IL-23水平是预测老年骨科创伤患者术后发生感染的独立危险因素(P<0.05),IL-6及IL-17水平是预测老年骨科创伤患者术后发生DVT的独立危险因素(P<0.05)。结论 IL-23水平是影响术后感染的独立危险因素,IL-17水平是预测DVT的独立危险因素,而IL-6同时是两者的独立危险因素。检测血清炎症因子水平对于预测该类患者并发症发生有较好的临床价值。
作者 赵海建
出处 《中国老年学杂志》 CAS 北大核心 2023年第20期5007-5009,共3页 Chinese Journal of Gerontology
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