自拟增液除燥方治疗干燥综合征的近远期疗效及对泪液和唾液分泌、血清炎性因子的影响

Short-long term efficacy of Zengye Chushifang on sjogren's syndrome and its influence on the tear and saliva production,serum inflammatory factor

目的:观察自拟增液除燥方治疗阴虚燥热型干燥综合征的近远期疗效及对泪液和唾液分泌、血清炎性因子的影响。方法:选取2020年1月~2021年8月在郑州市中心医院新郑分院就诊的77例干燥综合征患者作为研究对象。所有患者按照是否口服自拟增液化痹方分为观察组(n=42)和对照组(n=35)。对照组口服羟氯喹,观察组在对照组的基础上增加口服自拟增液化痹方。观察两组患者欧洲医学委员会风湿组干燥综合征评分量表(Eular sjogren's syndrome patient reported index,ESSPRI),欧洲医学委员会风湿组干燥综合征病程活跃程度(Eular sjogren's syndrome disease activity index,ESSDAI),泪液和唾液分泌,血清炎性因子[血沉(Erythrocyte sedimentation rate,ESR)、C-反应蛋白(C-reactive protein,CRP)、类风湿因子(Rheumatoid factor,RF)]的水平。比较两组临床疗效及安全性。结果:观察组治疗后及随访6m、12m总有效率均明显高于对照组(P<0.05)。治疗后,观察组ESSPRI、ESSDAI、ESR、CRP和RF水平均明显低于对照组(P<0.05),泪液流率和唾液流率明显高于对照组(P<0.05)。两组不良反应发生率无明显差异(P>0.05)。结论:自拟增液除燥方可有效缓解阴虚燥热型干燥综合征的患者的临床症状,增加泪液和唾液分泌,降低血清炎性因子水平。

Objective:To research the short-long term efficacy of Zengye Chushifang on sjogren's syndrome.Methods:A total of 77 patients with sjogren's syndrome were selected from Xinzheng Branch of Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2020 to August 2021.They were divided into observation group(n=42)and control group(n=35)according to whether or not orally took the Zengye Chushifang.The control group was given hydroxychloroquine,and the observation group was given Zengye Chushifang combined with hydroxychloroquine for 12 weeks.The Eular sjogren's syndrome patient reported index(ESSPRI),EULAR sjogren's syndrome disease activity index(ESSDAI),tear and saliva production,serum inflammatory factors[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF)]in the two groups were observed.The clinical efficacy and safety of the two groups were compared.Results:The total effective rates in the observation group were significantly higher than those in the control group after treatment and 6 months and 12 months of follow-up(P<0.05).After treatment,the ESSPRI,ESSDAI,ESR,CRP and RF in the observation group were significantly lower than those in the control group(P<0.05),and the tear flow rate and saliva flow rate were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Zengye Chushifang can effectively relieve the clinical symptoms of patients with sjogren's syndrome due to yin deficiency with internal heat,increase the secretion of tears and saliva,and reduce the level of serum inflammatory factors.