MSC来源外泌体治疗缺血性脑卒中机制及进展

Mechanism and Progress of MSC Derived Extracellular Vesicles in the Treatment of Ischemic Stroke

缺血性脑卒中是由于脑动脉血流中断从而导致细胞缺氧和氧化应激,同时激活炎症反应,造成组织细胞损伤,增加细胞凋亡和血液再灌注的风险。间充质干细胞可以通过诱导血管生成来改善缺血性脑卒中程度,同时间充质干细胞还具有抗凋亡,抗炎等诸多功能,被应用于卒中治疗。临床前期研究证实,间充质源外泌体通过靶向传递到受体细胞起到诱导血管生成,抗凋亡和抗炎的效果,也避免了间充质干细胞在治疗过程中存在的不足,进而用于卒中治疗。现系统地对间充质干细胞源外泌体在脑卒中中的作用机理进行总结,为缺血性脑血管病的临床治疗提供一种新的可能性,以期获得更好的治疗效果。

Cerebral ischemic stoke is a disease in which oxidative stress,activation of inflammatory storms,interference,induction of apoptosis,and blood reperfusion aggravate the tissue and cell damage due to ischemia and hypoxia.Mesenchymal stem cells(MSCs)induce the angiogenesis and can be used to treat the ischemiareperfusion injury,anti-apoptosis and anti-inflammatory.Preclinical studies have confirmed that targeted delivery of mesenchymal-derived exosomes to recipient cells exerts the effects of inducing angiogenesis,anti-apoptosis,and anti-inflammatory,while avoiding the shortcomings of mesenchymal stem cell therapy.The purpose of this study is to summarize the mechanism of exosomes derived from mesenchymal stem cells in the treatment of stroke so as to provide new opportunities for treating ischemic cerebrovascular disease clinically.