三组分反应合成5-(4-甲基苯基)-3-三氟甲基-1H-吡唑的综合实验设计

Comprehensive Experimental Design of Three Component Reaction for the Synthesis of 5-(4-Methylphenyl)-3-Trifluoromethyl-1H-Pyrazole

通过科研反哺教学,本实验将“多组分反应”和“含氟有机化合物”融入到本科实验教学中,通过三组分反应合成了5-(4-甲基苯基)-3-三氟甲基-1H-吡唑。该实验条件温和,操作简单,分离产率高,重现性好,安全性高。该综合实验能帮助学生理解步骤经济性合成的概念,建立绿色化学的理念,是适合引入有机实验教学课程的新课题。

Through scientific research back-feeding teaching,the two concepts of“multicomponent reaction”and“fluorinated organic compound”were integrated into undergraduate experiment teaching,and 5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazole was synthesized by the three-component reaction.This reaction features mild experimental conditions,simple operations,high yield,good reproducibility,and high safety.This comprehensive experiment integrates science and education and combines theory with practice,thus helping students to understand the new concept of step-economic synthesis and to establish the concept of green chemistry.This is a new subject suitable to introduce into the current organic experiment teaching course.