慢性心力衰竭合并肌少症的发病机制及干预

Pathogenesis and intervention of chronic heart failure complicated sarcopenia

肌少症是一种与增龄相关的肌肉质量、肌肉力量和身体功能逐渐下降的老年综合征,是老年人衰弱、残疾和死亡的有力预测因素。慢性心力衰竭通过营养不良、激素变化、炎症和氧化应激等多种病理生理机制促进肌少症的发生。而肌少症通过不同的机制促进慢性心力衰竭的发展,增加其不良预后的发生。本文主要阐述两种疾病的病理生理机制及其防治策略,为慢性心力衰竭的治疗提供新思路。

Sarcopenia is a geriatric syndrome with a gradual decline in muscle mass,muscle strength and physical function associated with aging,which is a strong predictor of frailty,disability,and death in the elderly.Chronic heart failure(CHF)promotes occurrence of sarcopenia through multiple pathophysiological mechanisms such as malnutrition,hormonal changes,inflammation and oxidative stress and so on.While sarcopenia promotes the development of CHF through different mechanisms and increases the occurrence of poor prognosis.The present article mainly elaborates the pathophysiological mechanisms and preventive&therapeutic strategies of the two diseases,providing new ideas for CHF treatment.