淀粉样蛋白-β在缺血性心脏病发病机制中的研究进展

Research progress of amyloid-β in pathogenesis of ischemic heart disease

淀粉样蛋白(AP)在中枢神经系统(CNS)中起着生理病理作用,其合成、浓度和清除率的改变与阿尔茨海默病(AD)和脑淀粉样血管病(CAA)等多种病理联系在一起。近期研究已提示AP在缺血性心脏病(IHD)和脑缺血-再灌注损伤(IRI)的发病机制中发挥作用。本综述通过阐述AP在CNS中的病理作用,探究AP在冠状动脉粥样硬化(CAS)发展中所起的作用及其在IHD和心脏IRI病理生理学中的可能意义。

Amyloid(AP)plays a physiological and pathological role in the central nervous system(CNS).The changes of its synthesis,concentration and clearance rate are associated with pathology of Alzheimer's disease(AD)and cerebral amyloid angiopathy(CAA)etc.Recent studies have suggested that AP plays a role in the pathogenesis of ischemic heart disease(IHD)and brain ischemia-reperfusion injury(IRI).The present review expounds the pathological role of AP in the CNS,explores the role of AP in the development of CAS and its possible significance in the pathophysiology of IHD and cardiac IRI.