膝骨关节炎致病危险因素的meta分析

Risk factors for knee osteoarthritis: a meta-analysis

目的:系统评价膝骨关节炎(KOA)的致病危险因素。方法:利用计算机检索万方、中国知网、维普、Web of Science、PubMed、Cochrane等数据库,收集有关KOA致病危险因素研究的文献,检索时间从建库至2022年6月,由2人独立对资料进行初步筛选和信息提取并进行质量控制,采用Cochrane官方提供的RevMan5.4软件进行meta分析。结果:本研究纳入12篇病例对照研究文献进行定量分析评价。meta分析结果显示:年龄(OR=1.08,95%CI[1.06,1.11])、女性(OR=2.67,95%CI[2.18,3.27])、BMI(OR=2.03,95%CI[1.50,2.73])、高强度锻炼(OR=1.89,95%CI[1.52,2.35])、经常性做蹲或跪的动作(OR=3.87,95%CI[1.09,13.77]、吸烟(OR=1.33,95%CI[1.24,1.43])、饮酒(OR=2.28,95%CI[1.42,3.66])、其他膝关节疾病史(OR=2.63,95%CI[1.36,5.08])和KOA家族史(OR=1.69,95%CI[1.36,2.11])是KOA的致病危险因素,而文化程度与KOA的发病无关。结论:提倡戒烟、戒酒、减少蹲或跪等动作、控制体质量及保持适量中低强度运动可以减少或延缓膝骨关节炎的发生;有膝关节外伤史与膝骨关节炎家族史的患者应注意保护膝关节,预防膝骨关节炎的发生。

Objective:To systematically evaluate the risk factors of knee osteoarthritis.Methods:We searched Wanfang,CNKI,VIP,Web of Science,PubMed,Cochrane and other databases by computer from the beginning of the database establishment to June 2022 to collect the literatures about the risk factors of knee osteoarthritis.Data were independently screened and extracted by 2 individuals for quality control,and a meta-analysis was performed using Cochrane RevMan 5.4 software.Results:A total of 12 Case-control study literatures were included in this study for quantitative analysis evaluation.Meta-analysis showed that age(OR=1.08,95%CI[1.06,1.11]),female(OR=2.67,95%CI[2.18,3.27]),BMI(OR=2.03,95%CI[1.50,2.73]),high-intensity exercise(OR=1.89,95%CI[1.52.2.35]),frequent squatting or kneeling(OR=3.87,95%CI[1.09,13.77]),smoking(OR=1.33,95%CI[1.24,1.43]),alcohol consumption(OR=2.28,95%CI[1.42,3.66]),history of other knee joint diseases(OR=2.63,95%CI[1.36,5.08])and family history of knee osteoarthritis(OR=1.69,95%CI[1.36,2.11])were the risk factors of knee osteoarthritis,while education level was not associated with knee osteoarthritis.Conclusion:In order to reduce or delay the occurrence of knee osteoarthritis,smoking cessation,alcohol abstinence,reduction of squatting or kneeling movements,weight control and moderate to low-intensity exercise should be advocated in daily life.Patients with a history of knee joint trauma and family history of knee osteoarthritis should pay attention to protect the knee joint and prevent the occurrence of knee osteoarthritis.