温补脾肾法治疗慢传输型便秘临床观察

Warming Spleen and Tonifying Kidney Method in the Treatment of Slow Transit Constipation

目的探讨温补脾肾法治疗慢传输型便秘(STC)的临床效果及对肠神经兴奋性递质P物质(SP)、神经降压素(NT)、胃泌素(GAS)的影响。方法选择九江市中医医院肛肠科收治的STC患者60例作为研究对象,按随机原则分成治疗组(中药温通汤煎服联合中药热奄包外敷)和对照组(枸橼酸莫沙必利片口服)各30例,均治疗、观察1个月,通过症状积分法分析治疗效果,进行疗效指标的观察。结果治疗前2组的症状积分及血清SP、NT、GAS含量差异均无统计学意义(P>0.05);治疗后治疗组患者的症状积分低于对照组(P<0.01),血清SP、NT、GAS含量均高于对照组(P<0.01或P<0.05);总有效率96.67%(29/30)高于对照组的80.00%(24/30)(P<0.01)。结论温补脾肾法治疗STC患者能显著改善临床症状、提升肠神经兴奋性递质含量、提高临床效果。

Objective To investigate the clinical efficacy of warming and tonifying the spleen and kidney method in the treatment of slow transit constipation(STC)and the influence on the excitatory transmitters SP,NT and GAS of intestinal nerve.Methods Sixty pa⁃tients with STC admitted to the Jiujiang Hospital of Traditional Chinese Medicine were selected as the study objects,and were ran⁃domly divided into the treatment group(Chinese medicine Wentong decoction combined with Chinese medicine external application of fomentation package)and the control group(oral Mosapride citrate tablet),with 30 cases in each group.Both were treated and ob⁃served for 1 month.The therapeutic effect was analyzed by symptom score method,and the therapeutic effect indexes were observed.Results Before treatment,there were no significant differences in symptom scores and serum SP,NT and GAS contents between 2 groups(P>0.05).After treatment,the symptom score of the treatment group was lower than that of the control group(P<0.01),and the serum SP,NT and GAS contents were higher than those of the control group(P<0.01 or P<0.05).The total effective rate was 96.67%(29/30),which was higher than that of the control group(80.00%,24/30)(P<0.01).Conclusion The intervention of warming spleen and tonifying kidney method in STC patients can significantly improve clinical symptoms,improve clinical efficacy and enhance the content of excitatory transmitter in intestinal nerve.