盐酸替罗非班氯化钠注射液联合心血管介入治疗急性心肌梗死的临床效果

Clinical Effect of Tirofiban Hydrochloride and Sodium Chloride Injection Combined with Cardiovascular Intervention in Treatment of Acute Myocardial Infarction

目的:探讨盐酸替罗非班氯化钠注射液联合心血管介入治疗急性心肌梗死的临床效果。方法:选取2018年6月—2022年6月新疆维吾尔自治区生产建设兵团第十师北屯医院收治的急性心肌梗死患者206例作为研究对象,随机分为两组,各103例。对照组实施心血管介入治疗,观察组在对照组基础上应用盐酸替罗非班氯化钠注射液治疗。比较两组胸痛程度、实验室指标及心血管不良事件、不良反应发生情况。结果:治疗前,两组疼痛评分及血清肌酸激酶同工酶(CK-MB)、高敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组疼痛评分、血清hs-CRP水平均低于治疗前,且观察组低于对照组,两组血清CK-MB水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组心血管不良事件总发生率低于对照组,差异有统计学意义(P=0.002)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸替罗非班氯化钠注射液联合心血管介入治疗急性心肌梗死的临床效果显著,能有效缓解患者胸痛程度,改善心功能,减轻炎性反应,减少心血管不良事件,且不会增加不良反应。

Objective:To investigate the clinical effect of tirofiban hydrochloride and sodium chloride injection combined with cardiovascular intervention in the treatment of acute myocardial infarction.Methods:A total of 206 patients with acute myocardial infarction treated in Beitun Hospital,The 10th Division,Xinjiang Uygur Autonomous Region Production and Construction Corps from June 2018 to June 2022 were selected as the study subjects.They were randomly divided into two groups with 103 cases in each group.The control group implemented cardiovascular intervention treatment,and the observation group was treated with tirofiban hydrochloride and sodium chloride injection on the basis of control group.The degree of chest pain,laboratory indicators,the incidence of cardiovascular adverse events and the incidence of adverse reactions in the two groups were compared.Results:Before treatment,there was no significant difference in pain score and serum creatine kinase isoenzyme(CK-MB)and high-sensitivity C-reactive protein(hs-CRP)levels between the two groups(P>0.05).After treatment,the pain score and serum hs-CRP level in the two groups were lower than those before treatment,and the observation group was lower than the control group;serum CK-MB level in the two groups was higher than those before treatment,and the observation group was higher than the control group,with statistically significant difference(P<0.05).The incidence of cardiovascular adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.002).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Tirofiban hydrochloride and sodium chloride injection combined with cardiovascular intervention in the treatment of acute myocardial infarction has significant clinical effects,it can effectively alleviate the degree of chest pain in patients,improve heart function,mitigate cardiovascular adverse events,and will not increase adverse reactions.