嵌入式经颅脉冲电刺激戒烟系统的设计

Design of an Embedded Transcranial Pulse Electrical Stimulation Smoking Cessation System

本文开发了一种新型的经颅脉冲刺激装置。该装置拟采用1~2 mA可控的经颅脉冲电刺激,即采用正负2个电极构成环路,在脑部施加1~2 mA可控的脉冲电流,并结合20 Hz的高频脉冲刺激脑部,使脑部神经元的静息膜电位发生变化,以调控其兴奋性,实现对脑部神经元的激活或抑制。此外,其能调控神经元间的突触联系,使神经元发生可塑性变化,起到神经调控的作用。研究表明,高频率脉冲电刺激能提高纹状体内多巴胺神经元的功能性连接,有望用于治疗烟碱成瘾。

This paper develops a new transcranial pulse stimulation device.The device is proposed to use 1~2 mA controlled transcranial pulse electrical stimulation,using positive and negative 2 electrodes to form a loop,applying 1-2 mA controlled pulse current in the brain and combining it with a high-frequency pulse stimulation of 20 Hz to the brain,so as to cause changes in the resting membrane potentials of the neurons of the brain in order to modulate their excitability,and to realize the activation or inhibition of the neurons in the brain.In addition,it can regulate the synaptic connection between neurons,so that neurons undergo plastic changes and play a neuromodulatory role.Studies have shown that high-frequency pulsed electrical stimulation improves the functional connectivity of dopamine neurons in the striatum,which is expected to be used in the treatment of nicotine addiction.