NF-κB信号通路参与调控支气管哮喘病理学特征研究新进展

New progress in the study of NF-κB signal pathway involved in the regulation of pathological characteristics of bronchial asthma

支气管哮喘(BA)是一种炎症性呼吸系统疾病,气道炎症、气道高反应、气道黏液高分泌及气道重塑是其主要病理学特征。核因子κB(NF-κB)信号通路作为炎症反应的共同通路,广泛参与BA气道炎症反应,NF-κB及其下游信号分子亦参与BA气道高反应、气道黏液高分泌以及气道重塑等病理学过程。本研究综述NF-κB信号通路参与调控BA病理学特征,为BA以及相关呼吸系统疾病的临床治疗与新药研究提供理论依据。

Bronchial asthma(BA)is an inflammatory respiratory disease,whose main pathological features are airway inflammation,hyperreactivity,hypersecretion of mucus and airway remodeling.The nuclear factor-κB(NF-κB)signaling pathway,as a common pathway of inflammatory response,is widely involved in BA airway inflammatory response,and NF-κB and its downstream signaling molecules are also involved in pathological processes such as BA airway hyperresponsiveness,airway mucus hypersecretion and airway remodeling.This study reviewed the involvement of NF-κB signaling pathway in regulating the pathological features of BA in recent years,and provides a theoretical basis for the clinical treatment and new drug research into BA and related respiratory diseases.