1990—2019年江苏省非酒精性脂肪肝疾病负担变化趋势分析

Trends in disease burden due to nonalcoholic fatty liver disease in Jiangsu Province from 1990 to 2019

目的掌握江苏省非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)疾病负担变化趋势,为制定防治策略提供依据。方法摘取2019年全球疾病负担数据(Global Burden of Disease Study 2019,GBD2019)中江苏省1990—2019年NAFLD的患病率、死亡率、伤残调整生命年(DALY)率及标化率,采用Joinpoint 4.2软件计算年度变化百分比(APC)。结果2019年江苏省NAFLD患病率、死亡率、DALY率分别为22.52%、1.35/10万、31.36/10万,标化率分别为16.04%、0.84/10万、19.73/10万,均随着年龄的增长而增长。1990—2019年江苏省NAFLD患病率总体呈上升趋势,30年上升了87.33%(APC=2.2%,t=7.8,P<0.01);死亡率总体呈下降趋势,30年下降了33.00%(APC=-2.2%,t=-3.6,P<0.01);DALY率总体呈下降趋势,30年下降了43.12%(APC=-2.8%,t=-4.3,P<0.01)。结论1990—2019年江苏省NAFLD患病率呈上升趋势,随着年龄的增加疾病负担增加。

Objective To investigate the trends in disease burden due to nonalcoholic fatty liver disease(NAFLD)in Jiangsu Province,so as to provide insights into the formulation of the NAFLD control strategy.Methods The prevalence,mortality,disability⁃adjusted life year(DALY),standardized prevalence,standardized mortality and standardized DALY rate of NALFD in Jiangsu Province from 1990 to 2019 were captured from the Global Burden of Disease Study 2019(GBD2019)dataset,and the trends in disease burden due to NALFD were evaluated with annual percent change(APC)using the software Joinpoint 4.2.Results The prevalence,mortali⁃ty,DALY rate of NAFLD were 22.52%,1.35/105 and 31.36/105,which all appeared a rise with age,and the standardized prevalence,mortality,DALY rate of NAFLD were 16.04%,0.84/105 and 19.73/105 in Jiangsu Province in 2019.The prevalence of NAFLD appeared an overall tendency towards a rise in Jiangsu Province from 1990 to 2019(APC=2.2%,t=7.8,P<0.01),and the mortality appeared an overall tendency towards a decline(APC=-2.2%,t=-3.6,P<0.01),while the DALY rate appeared an overall tendency towards a decline,with a 43.12%reduction over the 30 years(APC=-2.8%,t=-4.3,P<0.01).Conclusions The prev⁃alence of NAFLD appeared a tendency towards a rise in Jiangsu Province from 1990 to 2019,and the disease burden due to NAFLD increased with age.Early identification,early diagnosis and early treatment may improve the prognosis of NAFLD and patients’quality of life.