辅助生殖技术子代心血管健康及影响因素

Cardiovascular health status and influencing factors of offspring in assisted reproductive technology

辅助生殖技术(assisted reproductive technology,ART)帮助众多不孕夫妇孕育了新生命。随着ART出生人口占比逐渐增高,ART出生子代的健康问题引起越来越多的关注。生命早期具有的发育可塑性将环境因素与个体生长发育及疾病易感性联系起来,表观遗传学可能是其中的作用机制。心血管疾病(cardiovascular disease,CVD)是人类健康的首要威胁,ART治疗对子代心血管健康的影响非常值得重视。本文对ART子代心血管健康指标,以及ART各项技术和操作、亲代因素、宫内环境和生长模式对子代心血管健康产生的影响和潜在机制进行了综述。这将有助于临床医师及胚胎学家加深对ART安全性的理解和重视,促进技术和治疗过程的优化,进一步保障和改善子代健康。

With the help of assisted reproductive technologies(ART),many infertile couples fulfil their wish to have a child.The health of these offspring attracts growing attention as the proportion of ART births rises.Early-life developmental plasticity connects environmental influences to individual growth and disease susceptibility,epigenetics may be the mechanism.Since cardiovascular disease(CVD)is the primary threat to human health,the impact of ART on the cardiovascular health of offspring is of great importance.This paper reviews the cardiovascular health indicators of ART offspring,the effects and potential mechanisms arising from several techniques and procedures of ART,parental factors,intrauterine environment and growth patterns.This review will aid clinicians and embryologists in better understanding and focusing on the safety of ART technology,promoting the optimization of technology and treatment processes,and further securing and improving the health of patients.