亚洲人群CTLA-4基因(-318T/C)多态性与宫颈癌易感关系的Meta分析

Meta-analysis of the relationship between CTLA-4 gene(-318T/C)polymorphism and cervical cancer in Asia

目的 评估细胞毒性T淋巴细胞抗原基因-318T/C位点多态性与亚洲人群宫颈癌之间的相关性。方法 检索中英文数据库2023年3月前发表有关CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间关系的研究,OR值和95%CI作为评价指标,采用State11.0软件统计分析。结果 共纳入8项病例对照研究,病例组1497例和对照组1872例,Meta分析结果显示:CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间存在明显相关性(T vs C OR=1.59,95%CI:1.37~1.83;TC vs CC OR=1.57,95%CI:1.33~1.86;TT vs CC OR=3.53,95%CI:1.86~6.69;TT vs TC+CC OR=3.13,95%CI:1.65~5.93;TT+TC vs CC OR=1.64,95%CI:1.39~1.93),根据研究人群来源地区不同进行亚组分析发现CTLA-4基因-318T/C位点多态性与中国人群宫颈癌之间存在明显相关性,与印度和伊朗妇女不存在显著关联。结论 CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间存在明显相关性,特别是中国妇女。

Objective To evaluate the association between CTLA-4-318T/C gene polymorphism and cervical cancer in Asian women.Methods The studies about the relationship between CTLA-4-318T/C gene polymorphism and cervical cancer in Asian women were collected and the studies were published in Chinese and English databases before March 2023.The OR value and 95%CI were used as the evaluating indicators,and Meta-analysis was performed by using State 11.0 software.Results A total of 8 case-control studies were included,including 1497 cases and 1872 controls.The results of Meta-analysis showed that there was significant correlation between CTLA-4-318T/C gene polymorphisms and cervical cancer in Asian women(T vs C OR=1.59,95%CI:1.37-1.83;TC vs CC OR=1.57,95%CI:1.33-1.86;TT vs CC OR=3.53,95%CI:1.86-6.69;TT vs TC+CC OR=3.13,95%CI:1.65-5.93;TT+TC vs CC OR=1.64,95%C:1.39-1.93).Subgroup analysis based on different regions of the study population showed that there was significant correlation between CTLA-4-318T/C gene polymorphism and cervical cancer in the Chinese women,but there was no significant correlation with the Indian and Iranian women.Conclusion CTLA-4-318T/C gene polymorphism was significantly associated with cervical cancer in Asian women,especially in Chinese women.