摘要
目的 评估细胞毒性T淋巴细胞抗原基因-318T/C位点多态性与亚洲人群宫颈癌之间的相关性。方法 检索中英文数据库2023年3月前发表有关CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间关系的研究,OR值和95%CI作为评价指标,采用State11.0软件统计分析。结果 共纳入8项病例对照研究,病例组1497例和对照组1872例,Meta分析结果显示:CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间存在明显相关性(T vs C OR=1.59,95%CI:1.37~1.83;TC vs CC OR=1.57,95%CI:1.33~1.86;TT vs CC OR=3.53,95%CI:1.86~6.69;TT vs TC+CC OR=3.13,95%CI:1.65~5.93;TT+TC vs CC OR=1.64,95%CI:1.39~1.93),根据研究人群来源地区不同进行亚组分析发现CTLA-4基因-318T/C位点多态性与中国人群宫颈癌之间存在明显相关性,与印度和伊朗妇女不存在显著关联。结论 CTLA-4基因-318T/C位点多态性与亚洲人群宫颈癌之间存在明显相关性,特别是中国妇女。
Objective To evaluate the association between CTLA-4-318T/C gene polymorphism and cervical cancer in Asian women.Methods The studies about the relationship between CTLA-4-318T/C gene polymorphism and cervical cancer in Asian women were collected and the studies were published in Chinese and English databases before March 2023.The OR value and 95%CI were used as the evaluating indicators,and Meta-analysis was performed by using State 11.0 software.Results A total of 8 case-control studies were included,including 1497 cases and 1872 controls.The results of Meta-analysis showed that there was significant correlation between CTLA-4-318T/C gene polymorphisms and cervical cancer in Asian women(T vs C OR=1.59,95%CI:1.37-1.83;TC vs CC OR=1.57,95%CI:1.33-1.86;TT vs CC OR=3.53,95%CI:1.86-6.69;TT vs TC+CC OR=3.13,95%CI:1.65-5.93;TT+TC vs CC OR=1.64,95%C:1.39-1.93).Subgroup analysis based on different regions of the study population showed that there was significant correlation between CTLA-4-318T/C gene polymorphism and cervical cancer in the Chinese women,but there was no significant correlation with the Indian and Iranian women.Conclusion CTLA-4-318T/C gene polymorphism was significantly associated with cervical cancer in Asian women,especially in Chinese women.
作者
周青
刘帅妹
林宁
张瑞金
李孟兰
封婕
黄丽丽
吴玉璘
石慧
ZHOU Qing;LIU Shuaimei;LIN Ning;ZHANG Ruijin;LI Menglan;FENG Jie;HUANG Lili;WU Yulin;SHI Hui(Jiangsu Health Development Research Center,National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center,Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment,Nanjing,Jiangsu 210036,China)
出处
《中国优生与遗传杂志》
2023年第9期1839-1842,共4页
Chinese Journal of Birth Health & Heredity
基金
江苏省卫生健康发展研究中心自主科研项目(JSHD2021066)
江苏省科教能力提升工程(ZDXYS202210)
第三周期江苏省妇幼健康重点人才项目
江苏省卫生健康委科研项目(ZD2021030)。