原发性肺淋巴上皮瘤样癌的研究进展

Research progress of primary pulmonary lymphoepithelioma-like carcinoma

原发性肺淋巴上皮瘤样癌(PPLELC)是肺癌的一种独特类型,其组织学特征与鼻咽癌相似,发病与EB病毒相关,且血浆EB病毒DNA在PPLELC的进展、预后中具有预测价值。PPLELC不同于其他部分类型肺癌,其经典肺癌驱动基因突变率低,靶向治疗对其效果欠佳,化疗联合免疫治疗可能为晚期PPLELC患者的一线治疗方案。

Primary pulmonary lymphoepithelioma-like carcinoma(PPLELC)is a distinct type of lung cancer with histological profiles similar to nasopharyngeal carcinoma.The development is associated with EBV and plasma EBV DNA has predictive value in the progression and prognosis of PPLELC.PPLELC is different from some other types of lung cancer in that it has a low mutation rate of the classical lung cancer driver genes and targeted therapy is ineffective for it.Chemotherapy combined with immunotherapy may be the best first-line treatment option for patients with advanced PPLELC.