乳源性血管紧张素转换酶抑制肽的研究进展

Research Progress of Milk-derived Blood Pressure-lowering Peptides

高血压是威胁人类健康的“无声杀手”,乳源性ACE抑制肽是以乳类蛋白为原料经过酶解或发酵制备的具有降血压作用的肽。近年来,乳源性ACE抑制肽被认为是一种天然且相对安全的生物活性肽,因为具有生物活性高、毒性低、易代谢和良好的降压效果等特点而受到人们日益关注,并逐渐被应用到保健品、功能性食品等领域。本文综述了乳源性ACE抑制肽的来源(包括化学方法合成与天然食品来源)、制备方法(包括体外酶解与微生物发酵)。归纳总结了乳源ACE抑制肽的分离纯化及构效关系等方面的研究进展并简介在食品与临床方面的应用及未来发展前景,以期为推动我国开发ACE抑制肽有关产品提供参考。

Hypertension is a"silent killer"that threatens human health.Milk-derived antihypertensive peptides with antihypertensive activity are prepared from milk protein by enzymatic hydrolysis or fermentation.Recent years,milk-derived antihypertensive peptides have been regarded as a natural and relatively safe bioactive peptide,which have attracted increasing attention due to their high biological activity,low toxicity,easy metabolism and good antihypertensive effect.And milk-derived antihypertensive peptides have been gradually applied to health care products,functional foods and other fields.In this paper,the research progress in the sources(chemically synthesized and natural food sources)and preparation methods(digestibility in vitro and microbial fermentation).This paper summarizes the separation and purification,and structure-activity relationship of milk-derived antihypertensive peptides is reviewed,and the future development prospects for food and clinical applications are outlined,which will provide reference for promoting the development of antihypertensive peptide products in China.