急性心肌梗死后微血管阻塞与心肌内出血的机制研究进展

Pathogenesis of Microvascular Obstruction and Intramyocardial Hemorrhage After Acute Myocardial Infarction

微血管阻塞(MVO)是急性心肌梗死时发生的严重微循环障碍。心肌内出血(IMH)是在MVO的基础上,再灌注过程中发生的,是心肌梗死MVO形成后的二次损伤,和MVO的出现严格相关。急性心肌梗死时,梗死时间越长,梗死面积越大,心肌越容易出现MVO;再灌注时,越容易出现IMH。现从临床角度对急性心肌梗死后MVO和IMH的形成机制及相互关系进行综述。

Microvascular obstruction(MVO) is serious microvascular dysfunction in acute myocardial infarction.Intramyocardial hemorrhage(IMH) occurs during the reperfusion on the basis of MVO.It is the secondary injury after the formation of MVO in acute myocardial infarction and is strictly related to the occurrence of MVO.In acute myocardial infarction,the longer the infarct time and the larger the infarct area,the easier the myocardial MVO occurs;during the reperfusion,IMH is more likely to occur.From a clinical perspective,this article reviews the pathogenesis and interrelationships of MVO and IMH after acute myocardial infarction.