抗血管生成靶向药物相关性高血压的机制及研究进展

Mechanism of Hypertension Induced by Anti-Angiogenesis Targeting Drugs

近年来以抗血管生成通路为靶点而研发的新型抗肿瘤药物,在显著提高癌症患者存活率的同时,亦伴随出现了心脏毒性等副作用,而高血压是其最常见的副作用之一,也是许多心血管疾病的危险因素。现总结目前抗血管生成靶向药物相关性高血压可能的作用机制,包括一氧化氮信号通路和内皮素-1系统激活、氧化应激、血管收缩和舒张功能异常、PI3K/Akt信号通路的激活和盐敏感性高血压以及肾素-血管紧张素系统等。

Recently,new anti-tumor drugs,which are targeted at angiogenesis pathways,can significantly improve cancer survival,but also cause cardiotoxicity in some patients.Hypertension is the most common side effects,and it is a risk factor for many cardiovascular diseases as well.The article summarized the possible mechanisms of this kind of hypertension,including nitric oxide signaling pathway and endothelin-1 system,oxidative stress,abnormal vasomotor function,activation of PI3K/Akt pathway,salt-sensitive hypertension,and renin-angiotensin system,etc.