宫颈癌患者血清HE4、CEACAM6、AFP表达水平及其与临床病理特征的相关性

Serum levels of HE4,CEACAM6,and AFP in patients with cervical cancer and their correlation with clinical pathological characteristics

目的探究宫颈癌患者血清人附睾蛋白4(HE4)、癌胚抗原相关细胞黏附分子6(CEACAM6)、甲胎蛋白(AFP)表达水平及其与临床病理特征的相关性。方法选取2020年5月至2022年10月南阳南石医院妇产科收治的92例宫颈癌患者作为宫颈癌组,并选择同期46例宫颈上皮内瘤变患者作为良性组,46例健康体检者作为对照组。比较三组受检者的血清HE4、CEACAM6、AFP水平;采用Spearson相关性检验分析血清HE4、CEACAM6、AFP水平与临床病理特征相关性。结果宫颈癌组患者的血清HE4、CEACAM6、AFP水平分别为(124.79±15.35)pmol/L、(78.15±11.24)mg/L、(24.11±3.65)ng/mL,明显高于对照组的(37.54±3.11)pmol/L、(15.64±3.21)mg/L、(6.35±1.49)ng/mL和良性组的(75.61±8.57)pmol/L、(30.23±4.55)mg/L、(30.23±4.55)ng/mL,差异均有统计学意义(均P<0.001);不同淋巴结转移、分化程度、临床分期、浸润深度宫颈癌患者血清HE4、CEACAM6、AFP表达水平比较差异均有统计学意义(P<0.001);经Spearson相关性分析结果显示,血清HE4、CEACAM6、AFP与淋巴结转移、临床分期、浸润深度呈正相关(均P<0.001),与分化程度呈负相关(均P<0.001)。结论宫颈癌患者血清内HE4、CEACAM6、AFP呈高水平状态,且与宫颈癌患者的临床病理特征密切相关,可为宫颈癌的早期诊断提供参考依据。

Objective To investigate the correlation between the serum levels of human epididymal protein 4(HE4),carcinoembryonic antigen associated cell adhesion molecule 6(CEACAM6),alpha fetoprotein(AFP)in patients with cervical cancer and their correlation with clinical pathological characteristics.Methods Ninety-two patients with cervical cancer admitted to Nanyang Nanshai Hospital from May 2020 to October 2022 were selected as the cervical cancer group,46 patients with cervical intraepithelial neoplasia were selected as the benign group,and 46 healthy individuals were selected as the control group.The serum levels of HE4,CEACAM6,AFP were compared among the three groups.The correlation of HE4,CEACAM6,AFP with clinical pathological characteristics were analyzed by Spearson correlation test.Results The serum levels of HE4,CEACAM6,and AFP in the cervical cancer group were(124.79±15.35)pmol/L,(78.15±11.24)mg/L,and(24.11±3.65)ng/mL,respectively,which were significantly higher than(37.54±3.11)pmol/L,(15.64±3.21)mg/L,(6.35±1.49)ng/mL in the control group and(75.61±8.57)pmol/L,(30.23±4.55)mg/L,and(30.23±4.55)ng/mL in the benign group(P<0.001).The serum levels of HE4,CEACAM6,and AFP in different lymph node metastasis,differentiation,clinical stage,and depth of invasion of cervical cancer showed statistically significant differences(P<0.001).Spearson correlation analysis showed that serum levels of HE4,CEACAM6 and AFP were positively correlated with lymph node metastasis,clinical stage,and depth of invasion and negatively correlated with degree of differentiation(P<0.001).Conclusion The serum levels of HE4,CEACAM6,and AFP in the patients with cervical cancer are higher,which are closely related to clinical pathological characteristics,providing a reference basis for the diagnosis of cervical cancer.