甲基化酶DNMT3B、叉头框蛋白C1与宫颈癌超声特征的相关性分析

Correlation analysis of methylase DNMT3B,forkhead box protein C1 and ultrasound characteristics of cervical cancer

目的分析DNA甲基转移酶3B(DNA methyltransferase 3 beta,DNMT3B)、叉头框蛋白C1(forkhead box protein C1,FOXC1)与宫颈癌超声特征的相关性,以期为临床诊断宫颈癌提供更多的手段。方法选择我院收诊宫颈癌患者117例(研究组)与同期健康体检者50例(对照组)为研究对象,检测DNMT3B、FOXC1的表达,分析DNMT3B、FOXC1与彩色多普勒超声参数Adler分级、患者临床特征的关系,探究DNMT3B、FOXC1在宫颈癌中的临床意义。结果研究组DNMT3B、FOXC1高于对照组,且与Adler分级、糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(carbohydrate antigen 199,CA199)呈正相关(P<0.05)。DNMT3B与肿瘤大小、高危型人乳头瘤病毒(human papillomavirus,HPV)(-/+)、淋巴结是否发生转移、国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期有关,FOXC1则与肿瘤分化程度以及FIGO分期有关。结论宫颈癌中DNMT3B、FOXC1表达与宫颈癌动态超声结果有关,随着Adler分级的增加宫颈癌患者DNMT3B、FOXC1的表达水平也越来越高,且DNMT3B、FOXC1与CA125、CA199的表达均呈正相关,由此可见DNMT3B、FOXC1表达对宫颈癌的诊断有一定价值。

Objective To analyze the correlation between DNA methyltransferase 3B(DNMT3B),forkhead box protein C1(FOXC1)and ultrasonic characteristics of cervical cancer,in order to provide more means for clinical diagnosis of cervical cancer.Methods A total of 117 patients with cervical cancer admitted to our hospital(research group)and 50 healthy physical examinees(control group)during the same period were selected as the research subjects.The expression of DNMT3B and FOXC1 was detected,and the relationship of DNMT3B and FOXC1 with Adler rade of color Doppler ultrasound parameters and the clinical characteristics of patients was analyzed.The clinical significance of DNMT3B and FOXC1 in cervical cancer was explored.Results DNMT3B and FOXC1 in the research group were higher than those in the control group,which were positively correlated with Adler grade,carbohydrate antigen 125(CA125),and carbohydrate antigen 199(CA199)(P<0.05).DNMT3B was associated with tumor size,high-risk human papillomavirus(HR-HPV)(-/+),lymph node metastasis and international federation of gynecology and obstetrics(FIGO)stage.FOXC1 was related to tumor differentiation and FIGO stage.Conclusion DNMT3B and FOXC1 expression in cervical cancer is related to results of dynamic ultrasound for cervical cancer.DNMT3B and FOXC1 expression levels in cervical cancer patients increase with the increase of Adler grade,and DNMT3B and FOXC1 are positively correlated with CA125 and CA199 expression,suggesting that DNMT3B and FOXC1 expression has certain value in the diagnosis of cervical cancer.