双歧杆菌四联活菌辅助防治儿童腹型过敏性紫癜复发的临床疗效

Clinical efficacy of Bifidobacterium tetravalent live bacteria in the prevention and treatment of recurrence of abdominal allergic purpura in children

目的探讨双歧杆菌四联活菌防治儿童腹型过敏性紫癜复发的临床价值。方法选取2019年2月至2021年2月本院收治的82例腹型过敏性紫癜患儿作为研究对象,按照随机数字表法分为两组,各41例。两组均给予常规治疗,对照组口服泼尼松治疗,研究组在对照组基础上加用双歧杆菌四联活菌治疗,比较两组临床疗效、症状消失时间、炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-9(IL-9)、白细胞介素-23(IL-23)]、不良反应发生情况及复发情况。结果研究组治疗总有效率为95.12%,高于对照组的78.05%,差异有统计学意义(P<0.05)。研究组皮肤紫癜消失时间[(7.10±2.38)d]、关节肿痛消失时间[(4.13±1.02)d]及腹痛消失时间[(3.05±0.81)d]均短于对照组[(10.73±2.52)、(5.82±1.60)、(3.89±0.99)d],差异有统计学意义(P<0.05)。治疗30 d后,研究组TNF-α[(110.20±20.57)μg/L]、IL-9[(21.82±6.21)ng/L]、IL-23[(20.58±3.94)ng/L]水平均低于对照组[(150.28±24.13)μg/L、(29.51±7.54)ng/L、(27.64±4.71)ng/L],差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。随访3个月后,研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论双歧杆菌四联活菌防治儿童腹型过敏性紫癜复发效果显著,可有效减轻患儿机体炎症反应,促进临床症状消失,降低复发率,且安全可靠。

Objective To explore the clinical value of Bifidobacterium tetravalent live bacteria in prevention and treatment of recurrence of ab-dominal allergic purpura in children.Methods 82 children with abdominal allergic purpura admitted to our hospital from February 2019 to February 2021 were selected as the study subjects,they were divided into the two groups according to the random number table method,with 41 cases in each group.Both groups were given routine treatment,while the control group received oral prednisone treatment,and the study group received Bifidobac-terium tetravalent live bacteria on the basis of the control group,the clinical efficacy,symptom disappearance time,and inflammatory indicators(tu-mor necrosis factor-α[TNF-α],interleukin-9[IL-9],interleukin-23[IL-23]),incidence of adverse reactions and recurrence were compared between the two groups.Results The total effective rate in the study group was 95.12%,which was higher than 78.05%in the control group,the difference was statistically significant(P<0.05).The disappearance time of skin purpura([7.10±2.38]d),joint swelling and pain([4.13±1.02]d),and abdomi-nal pain([3.05±0.81]d)in the study group were shorter than those in the control group([10.73±2.52],[5.82±1.60],and[3.89±0.99]d),the differences were statistically significant(P<0.05).After 30 d of treatment,The levels of TNFα([110.20±20.57]μg/L),IL-9([21.82±6.21]ng/L),and IL-23([20.58±3.94]ng/L)were lower than those in the control group([150.28±24.13]μg/L,[29.51±7.54]ng/L,[27.64±4.71]ng/L),the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.After 3 month follow-up,the recurrence rate in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Bifidobacterium tetravalent live bacteria have significant effect on the prevention and treatment of recurrence of abdominal aller-gic purpura in children,which can effectively alleviate the inflammatory response of children,promote the disappearance of clinical symptoms,re-duce the recurrence rate,and is safe and reliable.