脑心通胶囊辅助治疗恢复期脑梗死的效果及对患者神经功能的影响

The effect of Naoxintong capsule in the adjuvant treatment of convalescent cerebral infarction and its impact on neurological function in patients

目的分析脑心通胶囊辅助治疗恢复期脑梗死的效果及对患者神经功能的影响。方法选取2019年1月至2021年1月本院收治的80例恢复期脑梗死患者作为研究对象,采用随机信封法分为对照组与观察组,每组40例。对照组给予常规西医治疗,观察组给予脑心通胶囊辅助治疗结合常规西医治疗,比较两组临床疗效及治疗前后神经功能评分、炎症因子指标、血脂水平、血液流变学指标。结果观察组治疗总有效率(92.50%)高于对照组(67.50%),差异有统计学意义(P<0.05)。两组美国国立卫生研究院卒中量表(NIHSS)评分组间、时间、交互比较差异有统计学意义(P<0.05);组内比较:治疗1、2、3周后,两组NIHSS评分均低于治疗前,且治疗后各时间点均低于前一时间点,差异有统计学意义(P<0.05);组间比较:治疗前,两组NIHSS评分比较差异无统计学意义;治疗1、2、3周后,观察组NIHSS评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组胆固醇、三酰甘油均低于治疗前,高密度脂蛋白胆固醇(HDL-C)水平均高于治疗前,且观察组胆固醇、三酰甘油低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血浆黏度、低切全血黏度、高切全血黏度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论脑心通胶囊辅助治疗恢复期脑梗死疗效显著,可改善炎症指标、血液流变学指标及血脂水平,有利于患者尽快康复,值得临床推广应用。

Objective To analyze the effect of Naoxintong capsule in the adjuvant treatment of convalescent cerebral infarction and its impact on neurological function of patients.Methods 80 patients with convalescent cerebral infarction admitted to our hospital from January 2019 to January 2021 were selected as the study subjects,and they were divided into the control group and the observation group according to the envelope method,with 40 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with Naox-intong capsule adjuvant therapy combined with conventional Western medicine,the clinical efficacy,neurological function scores,inflammatory fac-tor indicators,blood lipid levels,and hemorheological indicators before and after treatment were compared between the two groups.Results The total effective rate of the observation group(92.50%)was higher than that of the control group(67.50%),and the difference was statistically signifi-cant(P<0.05).There were significant differences in National Institute of Health stroke scale(NIHSS)between the two groups of group,time points and interaction(P<0.05).Comparison within groups:after 1,2 and 3 weeks of treatment,NIHSS scores of the two groups were lower than before treatment,and at all time points after treatment were lower than before previous time point,the difference was statistically significant(P<0.05).Comparison between groups:before treatment,there was no significant difference in NIHSS score between the two groups;after 1,2 and 3 weeks of treatment,the NIHSS score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and interleukin-18(IL-18)of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,cholesterol and triglyceride of the two proups were lower than before treatment,and high density lipoprotein-cholesterol(HDL-C)level was higher than before treatment,and cholesterol and triglyceride in the observation group were lower than that in the control group,and HDL-C level was higher than control group,the difference was statistically significant(P<0.05).After treatment,the plasma viscosity,low shear whole blood viscosity,and high shear whole blood viscosity of the two groups were lower than before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Naoxintong capsule has significant therapeutic effect on con-valescent cerebral infarction,improving inflammation indicators,blood rheology indicators,and blood lipid levels,which is beneficial for patients to recover as soon as possible and is worthy of clinical promotion and application.