双负荷剂量氯吡格雷联合阿司匹林治疗急性脑梗死的疗效研究

Clinical Efficacy of Double Loading Dose of Clopidogrel Combined with Aspirin in Acute Cerebral Infarction

目的:探究并分析双负荷剂量氯吡格雷联合阿司匹林对急性脑梗死患者的治疗效果。方法:选取2021年2月~2022年2月期间某院收治的69例急性脑梗死患者作为研究对象,按照随机数字表法分为对照组(n=34)和观察组(n=35)。对照组给予常规剂量氯吡格雷联合阿司匹林,观察组给予双负荷剂量氯吡格雷联合阿司匹林,两组均持续治疗45天。观察并记录两组患者的临床资料、血清S100钙结合蛋白A8/A9(S100A8/A9)水平、美国国立卫生研究院卒中量表(NIHSS)评分、临床疗效及不良反应发生情况。结果:治疗前,两组血清S100A8/A9水平比较无统计学差异(P>0.05);治疗1个月、3个月后,两组血清S100A8/A9水平较治疗前均降低(P<0.05),且观察组低于对照组(P<0.05);治疗前,两组NIHSS评分比较无统计学差异(P>0.05);治疗1个月、3个月后,两组NIHSS评分较治疗前均降低(P<0.05),且观察组低于对照组(P<0.05);观察组患者治疗总有效率(88.57%)高于对照组(67.65%,P<0.05);两组患者胃肠道反应及出血等不良反应总发生率比较无统计学差异(P>0.05)。结论:双负荷剂量氯吡格雷联合阿司匹林可有效提高急性脑梗死患者的治疗效果,改善神经功能,且安全性好。

Objective:To explore and analyze the therapeutic effect of the double loading dose of clopidogrel combined with aspirin in acute cerebral infarction.Methods:A total of 69 patients with acute cerebral infarction admitted to a certain hospital from February 2021 to February 2022 were divided into control group(n=34)and observation group(n=35)by random number table.The control group was treated with conventional dose of clopidogrel combined with aspirin,and the observation group was treated with double loading dose of clopidogrel combined with aspirin.Both groups were treated continuously for 45 days.The clinical data,the levels of serum S100 calcium binding proteins A8/A9(S100A8/A9),scores by National Institutes of Health Stroke Scale(NIHSS),clinical effect and adverse reactions in the two groups were observed and recorded.Results:Before treatment,there was no statistically significant difference in the levels of serum S100A8/A9 between the two groups(P>0.05).At 1 and 3 months post-treatment,the levels of serum S100A8/A9 in both groups were lower than those before treatment(P<0.05),and were decreased in the observation group as compared with the control group(P<0.05).Before treatment,there was no statistically significant difference in NIHSS scores between the two groups(P>0.05).At 1 and 3 months post-treatment,the NIHSS scores in both groups were lower than those before treatment(P<0.05),and were decreased in the observation group as compared with the control group(P<0.05).The total response rate in the observation group(88.57%)was higher than that in the control group(67.65%,P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions,including gastrointestinal reactions and bleeding,between the two groups(P>0.05).Conclusion:The double loading dose of clopidogrel combined with aspirin is effective in improving the therapeutic effect in patients with acute cerebral infarction and improving neurological function,with high safety profile.