慢性肾脏病患者微炎症状态的研究进展

Research Progress on Microinflammatory State in Patients with Chronic Kidney Disease

微炎症状态在慢性肾脏病(CKD)患者体内普遍存在,与CKD进程呈正相关,并参与多种CKD并发症(如营养不良、血管钙化、贫血等)的发生发展。尿毒症毒素等多种因素参与和促进了微炎症状态的发生发展,但其具体发病机制尚不清楚。新的炎症标志物增加了CKD患者微炎症状态评估的敏感性和便利性。药物治疗(尤其是中医药治疗)、优化透析等治疗手段对提高CKD微炎症状态患者生活质量、改善预后具有重要意义。

Microinflammatory state extensively exists in patients with chronic kidney disease(CKD),which is positively correlated with the progression of CKD and involved in occurrence and development of multiple complications of CKD(such as malnutrition,vascular calcification,anemia,etc.).Many factors including uremic toxins engage in and promote the occurrence and development of microinflammatory state,but relevant pathogenesis has not been fully elucidated.New inflammatory markers promoted the sensitivity and convenience of the evaluation of microinflammatory state in CKD patients.Treatment approaches such as drug therapy(especially traditional Chinese medicine)and optimized dialysis played an important role in improving the quality of life and the prognosis in CKD patients with microinflammatory state.