门冬胰岛素与地特胰岛素联治对妊娠期糖尿病患者血糖水平的影响分析

Effect Analysis of Combined Therapy of Insulin Aspart and Insulin Detemir on Blood Glucose Level in Patients with Gestational Diabetes Mellitus

目的 评价门冬胰岛素与地特胰岛素联治对妊娠期糖尿病患者血糖水平的影响。方法 选取2021年4月—2022年12月在福建省三明市大田县总医院妇产科就诊的78例妊娠期糖尿病患者,依据随机单盲法分为两组,各39例。对照组予以门冬胰岛素,观察组予以门冬胰岛素联合地特胰岛素,评价对比两组患者的血糖水平、妊娠结局、并发症发生率以及血糖达标情况。结果 治疗前,两组血糖水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的空腹血糖、餐后2 h血糖和糖化血红蛋白水平均显著低于对照组,差异有统计学意义(P<0.05)。相较于对照组不良妊娠结局和并发症发生率(25.64%、23.08%),观察组患者的不良妊娠结局(5.13%)和并发症发生率(5.13%)均明显更低,差异有统计学意义(χ^(2)=6.303、5.186,P<0.05)。观察组患者的血糖达标率(92.31%)比对照组(71.79%)高,其血糖达标时间(6.11±1.07)d短于对照组(8.98±1.43)d,差异有统计学意义(P<0.05)。结论 妊娠期糖尿病患者采取门冬胰岛素联合地特胰岛素治疗对降低血糖,改善妊娠结局和提高患者血糖达标率具有积极作用,值得临床采纳。

Objective To evaluate the effect of combined therapy of insulin aspart and insulin detemir on blood glucose level in patients with gestational diabetes mellitus.Methods 78 gestational diabetes mellitus patients who visited the Department of Obstetrics and Gynecology of Datian County General Hospital,Sanming City,Fujian Province from April 2021 to December 2022 were selected and divided into two groups according to a random single-blind method,with 39 cases in each group.The control group was given insulin aspart,and the observation group was given insulin aspart combined with insulin detemir two.The blood glucose level,pregnancy outcome,incidence of complications and blood glucose standard were evaluated and compared between the two groups.Results Before treatment,there was no statistically significant difference in blood glucose levels between the two groups(P>0.05);after treatment,the fasting blood glucose,2-hour postprandial blood glucose,and glycated hemoglobin levels of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Compared to the control group of adverse pregnancy outcomes and incidence of complications(25.64%,23.08%),the observation group had significantly lower adverse pregnancy outcomes(5.13%) and incidence of complications(5.13%),and the difference was statistically significant(χ^(2)=6.303,5.186,P<0.05).The blood glucose compliance rate of the observation group patients(92.31%) was higher than that of the control group(71.79%),and the blood glucose compliance time(6.11±1.07) d was shorter than that of the control group(8.98±1.43) d,and the difference was statistically significant(P<0.05).Conclusion The treatment of insulin aspart combined with insulin detemir in patients with gestational diabetes has a positive effect on lowering blood glucose,improving pregnancy outcomes and increasing the rate of blood glucose compliance,and it is worthy of clinical adoption.