低剖面可视化腔内支撑装置(LVIS支架)辅助弹簧圈栓塞技术治疗颅内破裂宽颈动脉瘤的效果

Efficacy of a low-profile visualized intraluminal support device(LVIS stent)-assisted coil embolization technique for treating intracranial ruptured wide-neck aneurysm

目的 研究低剖面可视化腔内支撑装置(LVIS支架)辅助弹簧圈栓塞技术治疗颅内破裂宽颈动脉瘤的效果,为临床提供参考。方法 选取2017年1月至2021年12月北京市房山区第一医院收治的88例颅内破裂宽颈动脉瘤患者为研究对象,按照随机数字表法分为对照组和观察组,各44例。对照组患者给予弹簧圈栓塞技术治疗,观察组患者给予LVIS支架辅助下的弹簧圈栓塞技术治疗。比较两组患者术后疗效、血管内皮相关指标水平及并发症发生情况。结果 观察组患者术后6个月的总有效率高于对照组(P<0.05)。观察组患者术后12个月的总有效率高于对照组(P<0.05)。术后,两组患者的内皮素-1(ET-1)及肿瘤坏死因子-α(TNF-α)水平低于术前,一氧化氮(NO)及一氧化氮合酶(NOS)水平高于术前,且观察组ET-1及TNF-α水平低于对照组,NO及NOS水平高于对照组(P<0.05)。观察组患者并发症发生率低于对照组(P<0.05)。结论 LVIS支架辅助弹簧圈栓塞技术对颅内破裂宽颈动脉瘤患者的临床效果好,可有效改善其血管内皮功能,减轻炎症反应。

Objective To study the effect of low-profile visualized intraluminal support device(LVIS stent)-assisted coil embolization technique in the treatment of intracranial ruptured wide-neck aneurysm,in order to provide a clinical reference.Methods 88 patients with intracranial ruptured wide-neck aneurysm treated in the First Hospital of Fangshan District,Beijing from January 2017 to December 2021 were selected.According to random number table method,they were divided into control group and observation group,44 cases in each group.Patients in control group were treated with coil embolization technique,and patients in observation group were treated with LVIS stent-assisted coil embolization technique.The postoperative efficacy,the level of vascular endothelial related indexes and the incidence of complications were compared between the two groups.Results The total effective rate of the observation group was higher at 6 months after surgery than that in the control group(P<0.05).The total effective rate of the observation group was higher at 12 months after surgery than that in the control group(P<0.05).After surgery,the levels of endothelin-1(ET-1)and tumor necrosis factor-α(TNF-α)in two groups were lower than before surgery,the levels of nitric oxide(NO)and nitric oxide synthase(NOS)were higher than before surgery.The levels of ET-1 and TNF-αin observation group were lower than those in control group,the levels of NO and NOS were higher than those in control group(P<0.05).The complication rate of the observation group was lower than the control group(P<0.05).Conclusion LVIS stent-assisted coil embolization technique has good clinical effect in patients with intracranial ruptured wide-neck aneurysm,and can effectively improve the vascular endothelial function and reduce inflammation.