大自体血回输疗法治疗内囊预警综合征患者的临床效果

Clinical effect of large autologous blood transfusion therapy in the treatment of patients with capsule warning syndrome

目的探讨大自体血回输疗法治疗内囊预警综合征(CWS)患者的临床效果。方法选取我院2010—2019年收治的46例CWS患者作为研究对象,根据入院时间不同将其分为对照组(2010—2015年)和观察组(2016—2019年),各23例。对照组给予传统常规治疗,观察组在对照组基础上加用大自体血回输疗法治疗。比较两组的治疗效果。结果治疗前,两组的S100B蛋白水平无显著差异(P>0.05);治疗14 d后,两组的S100B水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的美国国立卫生院神经功能缺损评分(NIHSS)评分无显著差异(P>0.05);治疗14 d后,两组的NIHSS评分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的预警症状发生率低于对照组,症状发作持续时间短于对照组,差异具有统计学意义(P<0.05);两组的改良Rankin量表评分(mRS)评分比较,差异无统计学意义(P>0.05)。结论大自体血回输疗法治疗CWS能够有效减少卒中预警症状发生率,改善卒中患者预后,减轻神经功能缺损程度,降低血清S100B蛋白水平,且不会增加不良反应,值得临床应用。

Objective To explore the clinical effect of large autologous blood transfusion therapy in the treatment of patients with capsule warning syndrome(CWS).Methods A total of 46 patients with CWS admitted in our hospital from 2010 to 2019 were selected as the research objects.According to the different admission time,the patients were divided into control group(2010 to 2015)and observation group(2016 to 2019),with 23 cases in each group.The control group was given traditional routine treatment,and the observation group was given large autologous blood transfusion therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results Before treatment,there was no significant difference in S100B protein level between the two groups(P>0.05);after 14 d of treatment,the level of S100B in the two groups decreased,and that in the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)score between the two groups(P>0.05);after 14 d of treatment,the NIHSS score of the two groups decreased,and that of the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of early warning symptoms in the observation group was lower than that in the control group,the duration of symptoms was shorter than that in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in Modified Rankin Scale(mRS)score between the two groups(P>0.05).Conclusion Large autologous blood transfusion therapy for CWS can effectively reduce the incidence of early warning symptoms,improve the prognosis of stroke patients,reduce the degree of neurological deficits,reduce serum S100B protein level,and will not increase adverse reactions,which is worthy of clinical application.