期刊文献+

门冬胰岛素联合医学营养治疗对妊娠期糖尿病患者血糖水平及胰岛β细胞功能的影响 被引量:6

Effects of insulin aspart combined with medical nutrition therapy on blood glucose level and isletβ-cell function in patients with gestational diabetes mellitus
下载PDF
导出
摘要 目的探讨门冬胰岛素联合医学营养治疗对妊娠期糖尿病患者血糖水平及胰岛β细胞功能的影响。方法选取2018年10月至2021年10月收治的350例妊娠期糖尿病患者为研究对象,随机将其分为对照组和观察组,各175例。对照组予以生物合成人胰岛素联合医学营养治疗,观察组采用门冬胰岛素联合医学营养治疗。比较两组的治疗效果。结果治疗后,观察组的空腹血糖(FBG)、餐后2 h血糖(2 h PBG)水平及糖化血红蛋白(HbA1c)均低于对照组(P<0.05)。治疗后,观察组的空腹胰岛素(FINS)水平、稳态模型胰岛素抵抗指数(HOMA-IR)低于对照组,稳态模型胰岛β细胞功能指数(HOMA-β)高于对照组(P<0.05)。治疗后,观察组的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均高于对照组,活性氧(ROS)水平低于对照组(P<0.05)。结论门冬胰岛素联合医学营养治疗有助于控制妊娠期糖尿病患者血糖水平,改善胰岛β细胞功能,减轻氧化应激反应,值得推广。 Objective To investigate the effects of insulin aspart combined with medical nutrition therapy on blood glucose level and isletβ-cell function in patients with gestational diabetes mellitus.Methods A total of 350 patients with gestational diabetes mellitus admitted from October 2018 to October 2021 were selected as the study objects and randomly divided into control group and observation group,with 175 cases in each group.The control group was given biosynthetic human insulin combined with medical nutrition therapy,and the observation group was given insulin aspart combined with medical nutrition therapy.The therapeutic effects of the two groups were compared.Results After treatment,the levels of fasting blood glucose(FBG),2 hours postprandial blood glucose(2 h PBG)and glycosylated hemoglobin(HbA1c)in the observation group were lower than those in the control group(P<0.05).After treatment,the fasting insulin(FINS)level and homeostasis model assessment of insulin resistance index(HOMA-IR)in the observation group were lower than those in the control group,and the homeostasis model assessment of isletβ-cell function index(HOMA-β)was higher than that in the control group(P<0.05).After treatment,the superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels in the observation group were higher than those in the control group,and reactive oxygen species(ROS)level was lower than that in the control group(P<0.05).Conclusion Insulin aspart combined with medical nutrition therapy can help to control the blood glucose level of gestational diabetes mellitus patients,improve the isletβ-cell function and reduce oxidative stress reaction,which is worth popularizing.
作者 赵菲 刘波艳 樊阳阳 ZHAO Fei;LIU Boyan;FAN Yangyang(the First Hospital of Weinan,Weinan 714000;Shaanxi Provincial People's Hospital,Xi'an 710068,China)
出处 《临床医学研究与实践》 2023年第29期133-137,共5页 Clinical Research and Practice
关键词 门冬胰岛素 医学营养治疗 妊娠期糖尿病 血糖 胰岛Β细胞功能 insulin aspart medical nutrition therapy gestational diabetes mellitus blood glucose isletβ-cell function
  • 相关文献

参考文献17

二级参考文献193

  • 1张慧芳.个体化营养治疗和运动疗法对妊娠期糖尿病的联合干预[J].深圳中西医结合杂志,2019,0(23):110-111. 被引量:11
  • 2吴金婵,陈娟,冯光球.利拉鲁肽联合门冬胰岛素对血糖控制不佳2型糖尿病患者胰岛β细胞功能及胰岛素抵抗的影响[J].兰州大学学报(医学版),2018,0(6):40-44. 被引量:11
  • 3Kahn CR.Joslin糖尿病学[M].14版.潘长玉,主译.北京:人民卫生出版社,2005:550-552.
  • 4中华医学会妇产科学分会产科学组,中华医学会围产医学分会妊娠合并糖尿病协作组.妊娠合并糖尿病临床诊断与治疗推荐指南(草案)[J].中华妇产科杂志,2007,42:426-428.
  • 5中华人民共和国国家卫生部.WS331-2011妊娠期糖尿病诊断[s]北京:中华人民共和国国家卫生部,2011.
  • 6International Association of Diabetes and Pregnancy 3tudy Groups Consensus Panel,Metzger BE,Gabbe SG, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy[J].Diabetes Care,2010,33:676-682.
  • 7International Diabetes Federation. Global Guideline on Pregnancy and Diabetes[S].Brussels: International Diabetes Federation,2009.
  • 8Walker JD. Diabetes in pregnancy:management of diabetes and its complications from pre-conception to the postnatal period. NICE guideline 63. London, March 2008[J]. Diabet Med, 2008, 25: 1025-1027.
  • 9Hoffman L,Nolan C,Wilson JD,et al.Gestational diabetes mellitus-management guidellnes.The Australasian Diabetes in Pregnancy Society[J].Med J Aust, 1998,169:93-97.
  • 10Canadian Diabetes Association.2008 CDA clinical practiceguidelines for the prevention and management of diabetes in Canada[J].Can J Diabetes,2008,32:S168-180.

共引文献1760

同被引文献69

引证文献6

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部