通络祛痛膏联合塞来昔布治疗风湿瘀阻证膝骨关节炎的效果

Effect of Tongluo Qutong Plaster Combined with Celecoxib in the Treatment of Knee Osteoarthritis with Syndrome of Rheumatism and Blood Stasis

目的:探讨通络祛痛膏联合塞来昔布治疗风湿瘀阻证膝骨关节炎(knee osteoarthritis,KOA)的效果。方法:选取2021年1—12月徐州市中心医院骨科收治的130例风湿瘀阻证KOA患者。根据简单信封随机法将其分为对照组和观察组,各65例。对照组给予塞来昔布胶囊,观察组在对照组基础上给予通络祛痛膏。比较两组治疗前后症状评分、临床疗效及不良反应。结果:治疗后,两组KOA严重性指数(index of severity of osteoarthritis,ISOA)评分低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组临床疗效优于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率略低于对照组,但差异无统计学意义(P>0.05),观察组未出现与中药外敷相关的局部皮肤过敏反应。结论:通络祛痛膏联合塞来昔布治疗KOA,能够缓解症状,且不增加药物相关的不良反应,用药安全性良好。

Objective:To investigate the effect of Tongluo Qutong Plaster combined with Celecoxib in the treatment of knee osteoarthritis(KOA)with syndrome of rheumatism and blood stasis.Method:A total of 130 KOA patients with syndrome of rheumatism and blood stasis admitted to the Department of Orthopedics of Xuzhou Central Hospital from January to December 2021 were selected.They were divided into control group and observation group according to simple envelope random method,65 cases in each group.The control group was given Celecoxib Capsules,and the observation group was given Tongluo Qutong Plaster based on the control group.Symptom scores before and after treatment,clinical efficacy and adverse reactions were compared between the two groups.Result:After treatment,the KOA index of severity of osteoarthritis(ISOA)score of both groups lower than those of before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the clinical efficacy of the observation group was better than that of the control group,and the total effective rate was higher than that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was slightly lower than that in the control group,but the difference was not statistically significant(P>0.05),and there was no local skin allergic reaction related to external application of traditional Chinese medicine in the observation group.Conclusion:Tongluo Qutong Plaster combined with Celecoxib in the treatment of KOA can relieve symptoms without increasing drug-related adverse reactions,and the drug safety is good.