卡前列素氨丁三醇预防高危产妇剖宫产产后出血的效果

Effect of Carboprost Tromethamine on Prevention of Postpartum Hemorrhage in High-risk Pregnant Women after Cesarean Section

目的:探究卡前列素氨丁三醇对高危产妇剖宫产产后出血的影响。方法:选取2021年10月—2022年10月中国融通医疗健康集团莆田九十五医院收治的107例高危产妇作为研究对象,采用电脑随机分组系统将其分为对照组(n=53)和观察组(n=54)。两组均于腰硬联合麻醉后接受剖宫产分娩,成功娩出胎儿后,对照组给予宫体内注射缩宫素治疗;观察组给予宫体内注射卡前列素氨丁三醇治疗。比较两组临床疗效、凝血功能指标水平、产后24 h出血量、止血时间。结果:观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组产后24 h出血量少于对照组,止血时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组凝血酶时间(TT)、纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)比较,差异无统计学意义(P>0.05);治疗后,观察组TT、PT、APTT均短于对照组,FIB高于对照组,差异有统计学意义(P<0.05)。结论:对剖宫产产后出血高危产妇实施卡前列素氨丁三醇治疗可以有效调节其凝血功能,快速止血,减少产后出血量,提高治疗效果。

Objective:To explore the effect of Carboprost Tromethamine on postpartum hemorrhage in high-risk pregnant women after cesarean section.Method:A total of 107 high-risk pregnant women admitted to China Rongtong Medical Health Group Putian 95 Hospital from October 2021 to October 2022 were selected as the study objects,and they were divided into control group(n=53)and observation group(n=54)according to computer randomization system.Both groups were delivered by cesarean section after combined epidural anesthesia.After the fetus was delivered successfully,the control group was given intrauterine injection of Oxytocin,the observation group was treated with intrauterine injection of Carboprost Tromethamine.The clinical efficacy,coagulation function index level,postpartum 24 h bleeding volume,hemostasis time of the two groups were compared.Result:The total effective rate of clinical treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The postpartum 24 h bleeding volume in the observation group was less than that in the control group,the hemostasis time was shorter than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant difference in thrombin time(TT),fibrinogen(FIB),prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).After treatment,TT,PT and APTT in the observation group were shorter than those in the control group,and FIB was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment of high-risk postpartum hemorrhage after cesarean section with Carboprost Tromethamine can effectively regulate the coagulation function,stop bleeding quickly,reduce the amount of postpartum bleeding and improve the therapeutic effect.