支气管镜肺泡灌洗术治疗难治性肺部感染的临床效果

Effect of Bronchoscopic Alveolar Lavage in the Treatment of Refractory Pulmonary Infection

目的:观察难治性肺部感染患者给予支气管镜肺泡灌洗术的临床治疗效果。方法:选取2022年2月—2023年2月黄河三门峡医院收治的77例难治性肺部感染患者。按照随机数表法将患者分成对照组38例,给予常规治疗,观察组39例给予支气管镜肺泡灌洗术治疗。比较两组治疗效果、不良反应、满意度、症状持续时间、住院时间、血清炎症细胞因子、肺功能指标。结果:观察组有效率、满意度均高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组发热时间、咳嗽咳痰时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)比较,差异无统计学意义(P>0.05);治疗后两组hs-CRP、IL-6、PCT均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。两组治疗前呼气流量峰值(PEF)、用力肺活量实际值占预计值的百分比(FVC%pred)、最大呼气中期流量(MMEF)比较,差异无统计学意义(P>0.05);治疗后,两组PEF、FVC%pred、MMEF均高于治疗前,观察组高于对照组,差异有统计学意义(P<0.05)。结论:在难治性肺部感染患者中,采用支气管镜肺泡灌洗术治疗能够提高治疗效果,改善症状,可降低炎症反应,改善肺功能,减少不良反应,缩短住院时间,提升满意度。

Objective:To observe the clinical effect of bronchoscopic alveolar lavage in patients with refractory pulmonary infection.Method:A total of 77 patients with refractory pulmonary infection admitted to Yellow River Sanmenxia Hospital from February 2022 to February 2023 were selected.According to the random number table method,38 cases in the control group were given conventional treatment,and 39 cases in the observation group were given bronchoscopic alveolar lavage.The therapeutic effect,adverse reactions,satisfaction,duration of symptoms,length of hospital stay,serum inflammatory cytokines and pulmonary function indexes were compared between the two groups.Result:The effective rate and satisfaction of the observation group were higher than those of the control group,and the incidence of adverse reactions was lower than that of the control group,the differences were statistically significant(P<0.05).The fever time,cough and sputum time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in interleukin-6(IL-6),procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)between the two groups(P>0.05).After treatment,hs-CRP,IL-6 and PCT in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in peak expiratory flow rate(PEF),the actual value of forced vital capacity as a percentage of the estimated value(FVC%pred)and maximum mid-expiratory flow(MMEF)between the two groups before treatment(P>0.05).After treatment,PEF,FVC%pred and MMEF in both groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:In patients with refractory pulmonary infection,bronchoscopic alveolar lavage can improve the therapeutic effect,improve symptoms,reduce inflammation,improve pulmonary function,reduce adverse reactions,shorten hospital stay,and improve satisfaction.