重组人干扰素α1b联合布地奈德、特布他林对喘息性支气管炎患儿的影响

Effects of Recombinant Human Interferon α1b Combined with Budesonide,Terbutaline in Children with Asthmatic Bronchitis

目的探讨重组人干扰素α1b联合布地奈德、特布他林对喘息性支气管炎患儿肺功能及T淋巴细胞亚群的影响。方法选取2019年1月至2022年7月诊治的102例喘息性支气管炎患儿作为研究对象,按照随机数字表法分为观察组(接受重组人干扰素α1b联合布地奈德、特布他林治疗)与对照组(接受布地奈德、特布他林治疗),各51例,对比喘息消失时间、肺部啰音消失时间、退热时间、咳嗽消失时间、住院时间、潮气呼气峰流速(PTEF)、第1秒用力呼气容积(FEV_(1))、达峰容积比(VPTEP/VE)、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)。结果观察组喘息消失时间、肺部啰音消失时间、退热时间、咳嗽消失时间、住院时间均短于对照组(P<0.05)。治疗7 d后,观察组的PTEF、FEV_(1)、VPTEP/VE、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论重组人干扰素α1b联合布地奈德、特布他林治疗喘息性支气管炎效果较好,有利于改善肺功能及调节T淋巴细胞亚群,且用药安全性高。

Objective To investigate the effects of recombinant human interferonα-1b combined with budesonide,terbutaline on lung function and T-lymphocyte subsets in children with asthmatic bronchitis.Methods A total of 102 children with asthmatic bronchitis diagnosed and treated from January 2019 to July 2022 were selected as research objects.According to the random number table method,they were divided into observation group(treated with recombinant human interferonα1b combined with budesonide,terbutaline)and control group(treated with budesonide,terbutaline),with 51 cases in each group.The time of disappearance of wheezing,the time for lung rales to disappear,the time of fever regression,the time of cough disappearance,the time of hospital stay,the peak expiratory velocity of moisture(PTEF),the forced expiratory volume in the first second(FEV_(1)),the peak volumeratio(VPTEP/VE)and CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+).Results The disappearance time of wheezing,time for lung rales to disappear,fever reduction time,cough disappearance time and hospital stay time of observation group were shorter than control group(P<0.05).After 7 days of treatment,PTEF,FEV_(1),VPTEP/VE,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in observation group were higher than those in control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of children(P>0.05).Conclusion Recombinant human interferonα1b combined with budesonide,terbutaline has an ideal effect in the treatment of asthmatic bronchitis,which is beneficial to improve lung function,and regulate T lymphocyte subsets,and the medication has high safety.